Strain SummaryB6.129P2-Xpatm1Hvs

Strain Name

B6.129P2-Xpatm1Hvs

Strain Type(s)

congenic  •  targeted mutation (knockout)

Strain Synonym(s)

C57BL/6 Xpa  •  C57Bl/6J-TgH(XPAIm)55Cmg  •  Xpa  •  Xpa homozygous knockout  •  Xpa-/-  •  XPA

Description

Homozygous mice. The genetic background of these mice is backcrossed C57BL/6J with the targeted mutation having been generated on a 129P2/OlaHsd background.

Strain Genetics

Xpatm1Hvs / Xpatm1Hvs

Models

111 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adipose tissue lipoma Abdominal cavity

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adipose tissue lipoma CNS - Brain

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adipose tissue lipoma CNS - Brain estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0

2.2

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0 - 1.1

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla diethylstilbestrol (DES)

0

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adrenal gland - Subcapsular cell hyperplasia Adrenal gland - Subcapsular cell

100

6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Adrenal gland - Subcapsular cell hyperplasia Adrenal gland - Subcapsular cell diethylstilbestrol (DES)

100

60 - 87

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Blood vessel hemangiosarcoma Blood vessel

0

0.6

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Bone lesion Bone - Sternum

0

6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Bone lesion Bone - Femur

0

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Bone lesion Bone - Sternum diethylstilbestrol (DES)

0 - 60

0 - 47

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Bone lesion Bone - Femur diethylstilbestrol (DES)

0 - 100

0 - 93

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Bone lesion - fibro-osseous Bone

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Bone lesion - fibro-osseous Bone estradiol (E2)

100

46.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Bone osteosarcoma Bone

0 - 0.6

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Bone osteosarcoma Bone diethylstilbestrol (DES)

0

0 - 6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Bone osteosarcoma Bone - Sternum diethylstilbestrol (DES)

6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Sites of Metastasis: not (Unspecified organ)

Bone osteosarcoma Bone estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

CNS - Brain - Cerebrum glioma CNS - Brain - Cerebrum

0

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

CNS - Brain - Cerebrum glioma CNS - Brain - Cerebrum diethylstilbestrol (DES)

0

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

CNS - Brain glioma CNS - Brain

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

CNS - Brain glioma CNS - Brain diethylstilbestrol (DES)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Connective tissue - Fibroblast fibrosarcoma Uterus - Cervix

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Connective tissue - Fibroblast fibrosarcoma Uterus - Cervix diethylstilbestrol (DES)

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Connective tissue - Fibroblast fibrosarcoma Skin

0

0.6

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Forestomach papilloma Forestomach benzo[a]pyrene (BP) (BaP) (B[a]P)

13

13

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Forestomach squamous cell carcinoma Forestomach benzo[a]pyrene (BP) (BaP) (B[a]P)

6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Forestomach tumor Forestomach benzo[a]pyrene (BP) (BaP) (B[a]P)

0 - 40

0 - 33.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Gallbladder papilloma Gallbladder 2-acetamidofluorene (2-AAF)

26.7

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Intestine - Large Intestine - Cecum adenoma Intestine - Large Intestine - Cecum benzo[a]pyrene (BP) (BaP) (B[a]P)

6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Intestine - Small Intestine - Duodenum adenocarcinoma Intestine - Small Intestine - Duodenum benzo[a]pyrene (BP) (BaP) (B[a]P)

6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Intestine - Small Intestine - Duodenum adenoma Intestine - Small Intestine - Duodenum benzo[a]pyrene (BP) (BaP) (B[a]P)

6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Intestine - Small Intestine - Ileum adenocarcinoma Intestine - Small Intestine - Ileum benzo[a]pyrene (BP) (BaP) (B[a]P)

6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Intestine - Small Intestine - Ileum adenoma Intestine - Small Intestine - Ileum benzo[a]pyrene (BP) (BaP) (B[a]P)

6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Intestine - Small Intestine - Jejunum adenocarcinoma Intestine - Small Intestine - Jejunum benzo[a]pyrene (BP) (BaP) (B[a]P)

20

20

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Intestine - Small Intestine - Jejunum adenoma Intestine - Small Intestine - Jejunum benzo[a]pyrene (BP) (BaP) (B[a]P)

20

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Intestine - Small Intestine adenocarcinoma Intestine - Small Intestine

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Intestine - Small Intestine adenocarcinoma Intestine - Small Intestine WY-14,643

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Intestine - Small Intestine tumor Intestine - Small Intestine

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Intestine tumor Intestine benzo[a]pyrene (BP) (BaP) (B[a]P)

0 - 46.7

0 - 26.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Kidney hyperplasia Kidney phenacetin

observed

observed

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Kidney transitional cell carcinoma Kidney p-cresidine

0

0 - 6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Kidney tumor Kidney phenacetin

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte - Lymphocyte - B-lymphocyte lymphoma Leukocyte - Lymphocyte - B-lymphocyte benzo[a]pyrene (BP) (BaP) (B[a]P)

20

13

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Sites of Metastasis: (Unspecified organ) , Liver

Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte

0

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte diethylstilbestrol (DES)

0

0 - 6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Sites of Metastasis: (Unspecified organ)

Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte benzo[a]pyrene (BP) (BaP) (B[a]P)

6.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Sites of Metastasis: (Unspecified organ) , Liver

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0

0.6

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte) estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte - Myelocyte (Granulocyte) sarcoma - myeloid Leukocyte - Myelocyte (Granulocyte)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte lymphoma Leukocyte

0 - 1.1

0 - 0.6

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte lymphoma Leukocyte benzo[a]pyrene (BP) (BaP) (B[a]P)

26.7 - 66.7

13.3 - 33.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte lymphoma Leukocyte Cyclosporin A

0 - 28.6

0 - 30.8

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte lymphoma Leukocyte diethylstilbestrol (DES)

0

0 - 6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte lymphoma Leukocyte estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte lymphoma Leukocyte WY-14,643

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver adenoma Liver

0

observed - 0.6

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver hepatocellular adenoma Liver

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver hepatocellular adenoma Liver WY-14,643

0 - 26.7

13.3 - 40

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver hepatocellular carcinoma Liver

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver hepatocellular carcinoma Liver estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver hepatocellular carcinoma Liver WY-14,643

0 - 6.7

0 - 6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver hyperplasia - oval cell Liver

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver hyperplasia - oval cell Liver WY-14,643

0 - 6.7

13.3 - 26.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver tumor Liver p-cresidine

6.7 - 20

0 - 53.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver tumor Liver 2-acetamidofluorene (2-AAF)

46.7

13.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Lung adenoma Lung

0 - 0.6

2.2 - 6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Lung adenoma Lung estradiol (E2)

6.7

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mammary gland adenocarcinoma Mammary gland

0

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mammary gland adenocarcinoma Mammary gland diethylstilbestrol (DES)

0

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mammary gland hyperplasia - focal Mammary gland

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Mammary gland hyperplasia - focal Mammary gland diethylstilbestrol (DES)

0 - 73

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Mesodermal cell/mesoblast sarcoma CNS - Brain

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma Abdominal cavity

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma Skin

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma Skin estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma CNS - Brain estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma Abdominal cavity estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Muscle - Smooth leiomyosarcoma Muscle - Smooth

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Ovary - Germ cell teratoma CNS - Brain

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Ovary - Germ cell teratoma CNS - Brain estradiol (E2)

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Ovary adenoma - tubulostromal Ovary

0.6

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Pituitary gland - Pars distalis hyperplasia Pituitary gland - Pars distalis

0

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Pituitary gland - Pars distalis hyperplasia Pituitary gland - Pars distalis diethylstilbestrol (DES)

0 - 87

0 - 60

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Pituitary gland - Pars intermedia hyperplasia Pituitary gland - Pars intermedia

0

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Pituitary gland - Pars intermedia hyperplasia Pituitary gland - Pars intermedia diethylstilbestrol (DES)

0 - 47

0 - 53

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Pituitary gland adenoma Pituitary gland

0

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Pituitary gland adenoma Pituitary gland diethylstilbestrol (DES)

0 - 13.3

0 - 33.3

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Placenta - Decidua deciduoma Placenta - Decidua

0.6

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Prostate gland - Anterior lobe metaplasia - squamous Prostate gland - Anterior lobe

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Prostate gland - Anterior lobe metaplasia - squamous Prostate gland - Anterior lobe diethylstilbestrol (DES)

0 - 60

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Testis - Germ cell teratoma CNS - Brain

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Testis - Germ cell teratoma CNS - Brain estradiol (E2)

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell)

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell) diethylstilbestrol (DES)

0 - 26.7

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20   ⋅   van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell)

0

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell) diethylstilbestrol (DES)

0 - 67

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

Thymus thymoma Thymus

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Urinary bladder preneoplastic lesion Urinary bladder p-cresidine

observed

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Urinary bladder tumor Urinary bladder p-cresidine

6.7

0 - 13.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Urinary bladder tumor Urinary bladder 2-acetamidofluorene (2-AAF)

6.7

20

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Uterus - Uterine gland hyperplasia Uterus - Uterine gland diethylstilbestrol (DES)

observed

References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20

(Unspecified organ) tumor (Unspecified organ)

0 - 4.5

0 - 7.2

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

(Unspecified organ) tumor (Unspecified organ) benzo[a]pyrene (BP) (BaP) (B[a]P)

66.7 - 93.3

26.7 - 53.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

(Unspecified organ) tumor (Unspecified organ) p-cresidine

13.3 - 26.7

0 - 60

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

(Unspecified organ) tumor (Unspecified organ) 2-acetamidofluorene (2-AAF)

46.7

26.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

(Unspecified organ) tumor (Unspecified organ) diethylstilbestrol (DES)

0 - 13.3

0 - 53.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27