Strain SummaryB6.129-Trp53tm1Tyj/+ Xpatm1Hvs
Strain Name |
B6.129-Trp53tm1Tyj/+ Xpatm1Hvs |
Strain Type(s) |
congenic • targeted mutation (knockout) |
Strain Synonym(s) |
C57BL/6 Xpa/p53 • combined Xpa homozygous and p53 heterozygous knockout • Xpa/p53 |
Description |
Mice were heterozygous for the Trp53 mutation and homozygous for the Xpa mutation. The genetic background of these mice is backcrossed C57BL/6 (most likely C57BL/6J). |
Strain Genetics |
Xpatm1Hvs / Xpatm1Hvs |
| Trp53tm1Tyj / Trp53+ |
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla | diethylstilbestrol (DES) |
0 |
6.7 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Subcapsular cell |
100 |
33 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Subcapsular cell | diethylstilbestrol (DES) |
93 |
93 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Bone lesion | Bone - Sternum |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Bone lesion | Bone - Femur |
6.7 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Bone lesion | Bone - Sternum | diethylstilbestrol (DES) |
60 |
53 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Bone lesion | Bone - Femur | diethylstilbestrol (DES) |
80 |
80 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Bone osteosarcoma | Bone |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Bone osteosarcoma | Bone | diethylstilbestrol (DES) |
13 |
33 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 Sites of Metastasis: Liver , Spleen |
|||
| Bone osteosarcoma | Leg | diethylstilbestrol (DES) |
27 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| CNS - Brain - Cerebrum glioma | CNS - Brain - Cerebrum |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| CNS - Brain - Cerebrum glioma | CNS - Brain - Cerebrum | diethylstilbestrol (DES) |
0 |
6.7 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Connective tissue - Fibroblast fibrosarcoma | Uterus - Cervix |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||||
| Connective tissue - Fibroblast fibrosarcoma | Uterus - Cervix | diethylstilbestrol (DES) |
6.7 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Leukocyte - Lymphocyte - T-lymphocyte lymphoma | Leukocyte - Lymphocyte - T-lymphocyte |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Leukocyte - Lymphocyte - T-lymphocyte lymphoma | Leukocyte - Lymphocyte - T-lymphocyte | diethylstilbestrol (DES) |
13 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 Sites of Metastasis: (Unspecified organ) |
|||
| Mammary gland adenocarcinoma | Mammary gland |
6.7 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||||
| Mammary gland adenocarcinoma | Mammary gland | diethylstilbestrol (DES) |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Mammary gland hyperplasia - focal | Mammary gland |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||||
| Mammary gland hyperplasia - focal | Mammary gland | diethylstilbestrol (DES) |
67 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Pituitary gland - Pars distalis hyperplasia | Pituitary gland - Pars distalis |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Pituitary gland - Pars distalis hyperplasia | Pituitary gland - Pars distalis | diethylstilbestrol (DES) |
73 |
73 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Pituitary gland - Pars intermedia hyperplasia | Pituitary gland - Pars intermedia |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Pituitary gland - Pars intermedia hyperplasia | Pituitary gland - Pars intermedia | diethylstilbestrol (DES) |
47 |
33 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Pituitary gland adenoma | Pituitary gland |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Pituitary gland adenoma | Pituitary gland | diethylstilbestrol (DES) |
13 |
13 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Prostate gland - Anterior lobe metaplasia - squamous | Prostate gland - Anterior lobe |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||||
| Prostate gland - Anterior lobe metaplasia - squamous | Prostate gland - Anterior lobe | diethylstilbestrol (DES) |
40 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Testis - Leydig cell (Interstitial cell) adenoma | Testis - Leydig cell (Interstitial cell) |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||||
| Testis - Leydig cell (Interstitial cell) adenoma | Testis - Leydig cell (Interstitial cell) | diethylstilbestrol (DES) |
27 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Testis - Leydig cell (Interstitial cell) hyperplasia | Testis - Leydig cell (Interstitial cell) |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||||
| Testis - Leydig cell (Interstitial cell) hyperplasia | Testis - Leydig cell (Interstitial cell) | diethylstilbestrol (DES) |
60 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Uterus - Uterine gland hyperplasia | Uterus - Uterine gland | diethylstilbestrol (DES) |
observed |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
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