Strain SummaryC57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs

Strain Name

C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs

Strain Type(s)

targeted mutation (knockout)

Strain Synonym(s)

C57Bl/6J-TgH(XPAIm)55Cmg x C57Bl/6J-TgH(p53Im)Δ26Cmg  •  Xpa-/-/p53+/-  •  XPA/p53

Description

Compound mutant mice. The genetic background of these mice was predominantly C57BL/6J. This cohort was generated by crossing 2 mutant strains each congenic for C57BL/6J.

Strain Genetics

Xpatm1Hvs / Xpatm1Hvs
Trp53tm1Tyj / Trp53+

Models

66 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adipose tissue lipoma Abdominal cavity

0.8

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adipose tissue lipoma CNS - Brain

6.7

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adipose tissue lipoma CNS - Brain estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0

2.2

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla diethylstilbestrol (DES)

0

6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Blood vessel hemangiosarcoma Blood vessel

0

1.5

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Bone lesion - fibro-osseous Bone

6.7

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Bone lesion - fibro-osseous Bone estradiol (E2)

66.7

33.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Bone osteosarcoma Bone

0 - 0.8

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Bone osteosarcoma Bone diethylstilbestrol (DES)

13.3

33.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Bone osteosarcoma Bone estradiol (E2)

0

20

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

CNS - Brain glioma CNS - Brain

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

CNS - Brain glioma CNS - Brain diethylstilbestrol (DES)

0

6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Connective tissue - Fibroblast fibrosarcoma Skin

0.8

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Connective tissue - Fibroblast fibrosarcoma Uterus - Cervix

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Connective tissue - Fibroblast fibrosarcoma Uterus - Cervix diethylstilbestrol (DES)

6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Gallbladder papilloma Gallbladder 2-acetamidofluorene (2-AAF)

13.3

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Intestine - Small Intestine tumor Intestine - Small Intestine

0

1.5

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Kidney adenoma Kidney phenacetin

observed

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Kidney hyperplasia Kidney phenacetin

observed

observed

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Kidney transitional cell carcinoma Kidney p-cresidine

6.7

13.3 - 20

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Kidney tumor Kidney phenacetin

observed

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0.8

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte) estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte - Myelocyte (Granulocyte) sarcoma - myeloid Leukocyte - Myelocyte (Granulocyte)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte lymphoma Leukocyte

0 - 2.3

0 - 13.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte lymphoma Leukocyte Cyclosporin A

40 - 50

13.3 - 72.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte lymphoma Leukocyte diethylstilbestrol (DES)

13.3

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Leukocyte lymphoma Leukocyte estradiol (E2)

13.3

6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver adenoma Liver

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver hepatocellular carcinoma Liver

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver hepatocellular carcinoma Liver estradiol (E2)

0

6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver tumor Liver p-cresidine

13.3

80 - 93.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Liver tumor Liver 2-acetamidofluorene (2-AAF)

26.7

6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Lung adenoma Lung

2.3 - 6.7

0 - 0.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Lung adenoma Lung estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mammary gland adenocarcinoma Mammary gland

1.5 - 6.7

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mammary gland adenocarcinoma Mammary gland diethylstilbestrol (DES)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma CNS - Brain

0.8 - 6.7

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma Abdominal cavity

0.8 - 6.7

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma Skin

46.7

40

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma Skin estradiol (E2)

33.3

20

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma CNS - Brain estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Mesodermal cell/mesoblast sarcoma Abdominal cavity estradiol (E2)

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Muscle - Smooth leiomyosarcoma Muscle - Smooth

0.8

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Ovary - Germ cell teratoma CNS - Brain

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Ovary - Germ cell teratoma CNS - Brain estradiol (E2)

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Ovary - Granulosa cell tumor Ovary - Granulosa cell

0.8

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Ovary adenoma - tubulostromal Ovary

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Pituitary gland adenoma Pituitary gland

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Pituitary gland adenoma Pituitary gland diethylstilbestrol (DES)

13.3

13.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Placenta - Decidua deciduoma Placenta - Decidua

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Testis - Germ cell teratoma CNS - Brain

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Testis - Germ cell teratoma CNS - Brain estradiol (E2)

6.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell)

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell) diethylstilbestrol (DES)

33.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Thymus thymoma Thymus

0.8

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell

0

0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Urinary bladder tumor Urinary bladder p-cresidine

13.3

40 - 46.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Urinary bladder tumor Urinary bladder 2-acetamidofluorene (2-AAF)

60

53.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

(Unspecified organ) tumor (Unspecified organ)

0 - 12.9

0 - 9.0

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

(Unspecified organ) tumor (Unspecified organ) p-cresidine

26.7

80 - 93.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

(Unspecified organ) tumor (Unspecified organ) 2-acetamidofluorene (2-AAF)

60

53.3

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

(Unspecified organ) tumor (Unspecified organ) diethylstilbestrol (DES)

46.7

86.7

References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27