STUDY SUMMARY

Breast (ER+) Cancer Model: TM00386

NSG™ mice engrafted with passage 6 tumors for model TM00386 were randomly assigned to one of these treatment groups:
  • 5% dextrose in water (vehicle control; 5 ml/kg; IV once per week for three times; N=8-10)
  • Cisplatin (2 mg/kg; IV once per week for three times; N=8-10)
  • Cyclophosphamide (40 mg/kg; IV once per week for three times; N=8-10)
  • Docetaxel (10 mg/kg; IV once per week for three times; N=8-10)
  • Doxorubicin (2 mg/kg; IV once per week for three times; N=8-10)
  • Tamoxifen (10 mg/kg; PO once daily for 21 days; N=8-10)
Mice were monitored for tumor volume at least twice per week throughout the study period.

• Treatment groups     • Individual subjects / spider plot     • RECIST scores     • Waterfall plot     • TGI plot         • Protocols


  TREATMENT GROUPS PLOT  

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  INDIVIDUAL SUBJECTS / SPIDER PLOT  

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  RECIST SCORES   
 




  WATERFALL PLOT   

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  TGI (TUMOR GROWTH INHIBITION) PLOT