PDX Model DetailsJ000077973

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PDX Model Summary

Model Details

Model ID
J000077973
Initial Diagnosis
Pancreatic adenocarcinoma
Final Diagnosis
Adenosquamous carcinoma
Stage/Grade
Not Specified /
Primary Site
Pancreas
Sample Site
Pancreas
Tumor Type
Primary Malignancy

Related Models

PDX models J000077960 and J000077973 originated from the same patient.

Patient

Sex
Female
Age (at time of tissue collection)
68
Race/Ethnicity
White / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample J000093625 from passage P0 has a TMB score of 3.23
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:J000093625 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P2 pathology is consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P2 tumor F005 ID014 for PDX model J000077973 stained for H&E. This is a 4x image.

P2 tumor F005 ID014 for PDX model J000077973 stained for H&E. This is a 20x image.

Dosing Studies

no data

Circos Plots

no data