PDX Model DetailsTM00335

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00335 (OV1828F)
Initial Diagnosis
Papillary serous adenocarcinoma
Final Diagnosis
Papillary serous adenocarcinoma
Stage/Grade
III /
Primary Site
Ovary
Sample Site
Ovary
Tumor Type
Primary Malignancy

Publications citing this model

 Jin, L; et al. MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation. Cancer Cell. 2018 Aug 13;34(2):315-330.e7.  10.1016/j.ccell.2018.06.012
Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
89
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample OV1828F081P0 from passage P0 has a TMB score of 5.66
Sample OV1828F082P0000P1008P2 from passage P2 has a TMB score of 3.23
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:OV1828F081P0 from passage P0     Score:MSI-S
Sample:OV1828F082P0000P1008P2 from passage P2     Score:MSI-S

Gene Fusion
Fusion Genes
Sample OV1828F082P0000P1012P2 has fusion genes MTG1--SCART1, PDXDC1--NPIPB14P, TVP23C--CDRT4, LIMS1--AC140479.3, RBM14--RBM4B, SMBD1P--MUC20P1, CFAP45--VSIG8, DLEU2--MTUS2, AC010896.1--SELENOI, BOLA2B--SMG1P2, LINC02257--LINC01655, CASC9--AC100782.1, OR51S1--TP53I11, SCNN1A--TNFRSF1A, AL078587.2--AL390198.2, AC004596.1--AC003102.1, TEX15--GTF2E2, SDHA--AC091849.2

Model Characterization

Histology

 Summary:
P6 pathology consistent with ovarian serous carcinoma, fidelity to P6.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F082 for PDX model TM00335 stained for H&E.
P6 tumor F082 ID004 for PDX model TM00335 stained for H&E.

Dosing Studies

Circos Plots

 no data