PDX Model DetailsTM00913

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00913 (OV1056F)
Initial Diagnosis
Ovary serous adenocarcinoma
Final Diagnosis
Ovary serous adenocarcinoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Ovary
Sample Site
Ovary
Tumor Type
Primary Malignancy

Related Models

 PDX models TM00913, TM00914 and TM00916 originated from the same patient.

Patient
Sex
Female
Age (at time of tissue collection)
68
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden

 no data

Microsatellite Instability

 no data

Gene Fusion
Fusion Genes
Sample OV1056F031P0 has fusion genes GUSBP16--AP000346.2, DNM1L--FGD4, LDLRAP1--AL606491.1, SYS1--DBNDD2, SMAD3--LINC02853, AL512324.3--RSU1P2, GON4L--AL353807.5, HERC2P10--AC087481.2, ITPR2--TM7SF3, SCAI--LINC01411, ABCC1--NDE1, HECTD4--RPL6, LAMC2--AL354953.1, SMBD1P--MUC20P1, SCHLAP1--UBE2E3, AC008667.1--UBE2D2, RNF123--IHO1, MAML1--RUFY1, SUPV3L1--KIFBP, ARPIN--AP3S2, MDN1--BACH2, AC008443.2--AC008443.5, ARPC4--TTLL3, ERI3--EIF2B3, NARF--LIN52, CAPN1--CAPN2, SMURF2P1--LRRC37B, ZBTB17--WDFY3-AS1, PFKFB3--LINC02649, ZNF880--AC010332.1, PDZD8--EMX2OS, TEAD2--NUP62, MYEOV--CROCC, RBM14--RBM4, HK1--KIFBP, BMERB1--NDE1, RXRA--SAXO1, SLC25A13--RLF, ABCC1--BMERB1, TPTEP2--CSNK1E, UIMC1--LMAN2, KMT2C--TPTE, RBM14--RBM4B, AL512590.2--CCDC180, SLC6A6--BCAR4, KLHL5--AC079921.2, DCTN1--SLC4A5, ATXN10--ANKS1A, GPCPD1--MAP4, XPO5--DSN1, AL391840.3--SH3BGRL2, MTG1--SCART1, NUDT3--ILRUN, PDXDC1--NPIPB14P, PKD1--NPIPP1, LINC02159--ATP10B, PSPC1--MRPS31P2, VAMP8--VAMP5, LEPROT--LEPR, LINC02831--PPP3R1, NCK1--IL20RB, UACA--SPDYE2, USP39--NFE2, CEP43--CCR6, TXNDC11--FBLN2, FGFR3--NSD2, PCM1--EIF4EBP1, EFCAB14--ATPAF1, TVP23C--CDRT4, AL390860.1--TRIM58, ARID5B--CABCOCO1, RALY--CBFA2T2, ARHGEF5--OR2A7, ZNF8--ERVK3-1, AL133410.1--NPR2, PVT1--PCM1, VIPAS39--NOXRED1, AEBP2--PLEKHA5, SMARCC1--GCDH, MNAT1--SLC38A6, ADIPOR2--ERC1, CPSF6--CHMP1A, VMP1--RNFT1-DT, STX16--NPEPL1, SIAH2--AC011317.1, KRT5--KRT84, SLC6A6--GSPT1, ZNF675--ZFP14, POLR3F--PET117, PDCL--DENND1A, SAMD12--MRPL13, AKAP13--PDE8A, DSN1--CDK12, NACC2--UNC13B, POLR2J3--AC004951.2, ASLP1--AP000346.2, LINC00630--Z68871.1, DNM2--LRRC37A4P, RBPMS2--SMYD3, CRYZL2P--SEC16B, AC004951.2--RASA4, NDUFB8--SEC31B, AL078587.2--AL390198.2, SCGB2B2--SCGB1B2P, UBE2Q2P1--GOLGA6L9, SLC22A18--KCNQ1, SLC6A6--ZC3H7A, DDX10--ATM, PABPC1L--OSCP1, PRRG2--AP2A1, IFT57--CIP2A, RNASET2--RPS6KA2, AC080129.2--IRAG2, RDH13--FIZ1, PCDHA4--PCDHAC1, MECOM--LRRC31, RNASEH1--AC108488.1, PARP6--HIGD2B, CECR7--AC006946.2, BLOC1S5--TXNDC5, WDFY3-AS1--ARHGEF19, NRIP1--LINC02246, TTC39C--TMEM184B

Model Characterization

Histology

 Summary:
P1 pathology consistent with adenocarcinoma. P3 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F031 ID123 for PDX model TM00913 stained for AE1AE3. Staining was positive.
P1 tumor F031 ID123 for PDX model TM00913 stained for CD45. Staining was negative.

P1 tumor F031 ID123 for PDX model TM00913 stained for Ki67. Staining was positive.
P3 tumor F031 ID019 for PDX model TM00913 stained for H&E.

P3 tumor F031 ID019 for PDX model TM00913 stained for AE1AE3. Staining was positive.
P3 tumor F031 ID019 for PDX model TM00913 stained for CD45. Staining was negative.

P3 tumor F031 ID019 for PDX model TM00913 stained for Ki67. Staining was positive.

Dosing Studies

 no data

Circos Plots

 no data