Reference SummaryMaita K, Toxicol Pathol 1988;16(3):340-9
Title |
Mortality, major cause of moribundity, and spontaneous tumors in CD-1 mice. | ||||
Authors |
Maita K; Hirano M; Harada T; Mitsumori K; Yoshida A; Takahashi K; Nakashima N; Kitazawa T; Enomoto A; Inui K; et al. | ||||
Journal |
Toxicol Pathol | ||||
Volume |
16 | ||||
Issue |
3 | ||||
Year |
1988 | ||||
Pages |
340-9 | ||||
Abstract |
Mortality, major causes of moribundity, and spontaneous tumors in CD-1 mice were studied in 891 males and 890 females, which were used as controls in 11 different 2-year chronic and oncogenicity studies during the past 5 years. Average mortality of males and females at 83 weeks of age was 32.6% and 28.6%, respectively, and at 109 weeks of age was 66.4% and 63.3%, respectively. Mortality was significantly lowered in males and females born after 1980 in accordance with an abruptly decreased occurrence of systemic amyloidosis in these animals. The major cause of death or moribundity included systemic arteritis, systemic amyloidosis, auricular thrombosis, glomerulosclerosis, lymphoma, and pulmonary adenocarcinoma in both sexes. Dysuria and hepatocellular carcinoma in males and mammary adenocarcinoma in females were also critical lesions. The major tumors occurring at more than 3% incidence were systemic lymphoma, adenoma/adenocarcinoma of the lung, adenoma/carcinoma of the liver and adenoma/adenocarcinoma of the Harderian gland for males, and systemic lymphoma, adenoma/adenocarcinoma of the lung, adenoma/carcinoma of the liver, leiomyoma/leiomyosarcoma of the uterus, adenoma/adenocarcinoma of the pituitary (anterior), adenoma/adenocarcinoma of the mammary gland and adenoma/adenocarcinoma of the Harderian gland for females. Intralaboratory heterogeneities in the incidence were recorded as follows: systemic lymphoma in 1 of 11 control groups (1/11) and adenoma/adenocarcinoma in 1/11 for males, and systemic lymphoma in 3/11, adenoma/adenocarcinoma of the lung in 2/11, adenoma/adenocarcinoma of the liver in 1/11, and adenoma/adenocarcinoma in 1/11 for females. | ||||
Links |
J:166044 – MGI References 3194656 – National Library of Medicine/PubMed |
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Strain Notes
|
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| CD-1 | Adipose tissue lipoma | Kidney |
0 - 0.1 |
||
| CD-1 | Adipose tissue lipoma | Abdominal cavity |
0.1 |
||
| CD-1 | Adipose tissue liposarcoma | Subcutis |
0 - 0.8 |
||
| CD-1 | Adipose tissue liposarcoma | Abdominal cavity |
0 - 0.1 |
||
| CD-1 | Adrenal gland - Cortex adenocarcinoma | Adrenal gland - Cortex |
0 - 0.3 |
||
| CD-1 | Adrenal gland - Cortex adenoma | Adrenal gland - Cortex |
0.4 - 0.9 |
||
| CD-1 | Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
0.3 - 0.6 |
||
| CD-1 | Adrenal gland - Medulla pheochromocytoma - malignant | Adrenal gland - Medulla |
0 - 0.1 |
||
| CD-1 | Blood vessel hemangioma | Spleen |
0.6 - 0.8 |
||
| CD-1 | Blood vessel hemangioma | Lymph node |
0 - 0.1 |
||
| CD-1 | Blood vessel hemangioma | Lung |
0 - 0.1 |
||
| CD-1 | Blood vessel hemangioma | Intestine - Small Intestine |
0 - 0.1 |
||
| CD-1 | Blood vessel hemangioma | Liver |
0.4 - 1.5 |
||
| CD-1 | Blood vessel hemangioma | Epididymis |
0.1 |
||
| CD-1 | Blood vessel hemangioma | Subcutis |
0.4 - 0.9 |
||
| CD-1 | Blood vessel hemangioma | Muscle |
0 - 0.1 |
||
| CD-1 | Blood vessel hemangioma | Abdominal cavity |
0 - 0.3 |
||
| CD-1 | Blood vessel hemangioma | Ovary |
0.4 |
||
| CD-1 | Blood vessel hemangioma | Uterus |
0.9 |
||
| CD-1 | Blood vessel hemangiosarcoma | Spleen |
0.4 - 0.7 |
||
| CD-1 | Blood vessel hemangiosarcoma | Lymph node |
0 - 0.1 |
||
| CD-1 | Blood vessel hemangiosarcoma | Liver |
0.1 - 0.4 |
||
| CD-1 | Blood vessel hemangiosarcoma | Muscle |
0 - 0.1 |
||
| CD-1 | Blood vessel hemangiosarcoma | Abdominal cavity |
0.1 |
||
| CD-1 | Blood vessel hemangiosarcoma | Ovary |
0.1 |
||
| CD-1 | Blood vessel hemangiosarcoma | Uterus |
0.1 |
||
| CD-1 | Blood vessel tumor | Subcutis |
0.3 - 0.8 |
||
| CD-1 | Bone osteoma | Spleen |
0 - 0.1 |
||
| CD-1 | Bone osteoma | Bone |
0 - 0.2 |
||
| CD-1 | Bone osteoma | Bone - Skull |
0 - 0.1 |
||
| CD-1 | Bone osteosarcoma | Bone |
0.2 |
||
| CD-1 | Bone osteosarcoma | Abdominal cavity |
0 - 0.1 |
||
| CD-1 | CNS - Meninges meningioma - malignant | Bone - Skull |
0 - 0.1 |
||
| CD-1 | Connective tissue - Fibroblast fibroma | Subcutis |
0.1 - 0.3 |
||
| CD-1 | Connective tissue - Fibroblast fibroma | Uterus |
0.1 |
||
| CD-1 | Connective tissue - Fibroblast fibrosarcoma | Pancreas |
0 - 0.1 |
||
| CD-1 | Connective tissue - Fibroblast fibrosarcoma | Subcutis |
0.9 - 1.7 |
||
| CD-1 | Connective tissue - Fibroblast fibrosarcoma | Ear - Outer ear |
0 - 0.1 |
||
| CD-1 | Eye - Harderian gland adenocarcinoma | Eye - Harderian gland |
0.2 - 0.4 |
||
| CD-1 | Eye - Harderian gland adenoma | Eye - Harderian gland |
6.9 - 10.2 |
||
| CD-1 | Forestomach squamous cell carcinoma | Forestomach |
0.1 - 0.3 |
||
| CD-1 | Gallbladder papilloma | Gallbladder |
0.1 |
||
| CD-1 | Intestine - Large Intestine - Anus adenoma | Intestine - Large Intestine - Anus |
0 - 0.1 |
||
| CD-1 | Intestine - Large Intestine - Anus squamous cell carcinoma | Intestine - Large Intestine - Anus |
0 - 0.1 |
||
| CD-1 | Intestine - Large Intestine squamous cell carcinoma | Intestine - Large Intestine |
0 - 0.1 |
||
| CD-1 | Intestine - Small Intestine adenocarcinoma | Intestine - Small Intestine |
0 - 0.2 |
||
| CD-1 | Intestine - Small Intestine adenoma | Intestine - Small Intestine |
0.1 - 0.2 |
||
| CD-1 | Kidney adenocarcinoma | Kidney |
0.1 |
||
| CD-1 | Kidney adenoma | Kidney |
0.1 - 0.3 |
||
| CD-1 | Kidney carcinoma | Kidney |
0 - 0.2 |
||
| CD-1 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant | Spleen |
0.1 |
||
| CD-1 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant | Stomach |
0 - 0.1 |
||
| CD-1 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant | Liver |
0.1 - 0.3 |
||
| CD-1 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant | Subcutis |
0 - 0.1 |
||
| CD-1 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant | Thoracic cavity |
0 - 0.1 |
||
| CD-1 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant | Uterus |
0.1 |
||
| CD-1 | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell mastocytoma | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell |
0 - 0.2 |
||
| CD-1 | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell mastocytoma - malignant | Subcutis |
0 - 0.1 |
||
| CD-1 | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
1.8 - 1.9 |
||
| CD-1 | Leukocyte leukemia - unclassified | Leukocyte |
0.1 |
||
| CD-1 | Leukocyte lymphoma | Leukocyte |
4.3 - 29.7 |
||
| CD-1 | Leukocyte lymphoma | Thymus |
0.6 - 1.2 |
||
| CD-1 | Leukocyte lymphoma | Spleen |
0.4 - 0.9 |
||
| CD-1 | Leukocyte lymphoma | Lymph node |
0.6 |
||
| CD-1 | Leukocyte lymphoma | Intestine - Small Intestine |
0 - 0.2 |
||
| CD-1 | Leukocyte lymphoma | Kidney |
0 - 0.1 |
||
| CD-1 | Liver - Bile duct cholangiocarcinoma | Liver - Bile duct |
0 - 0.1 |
||
| CD-1 | Liver - Bile duct cholangioma | Liver - Bile duct |
0 - 0.1 |
||
| CD-1 | Liver hepatoblastoma | Liver |
0 - 0.4 |
||
| CD-1 | Liver hepatocellular adenoma | Liver |
5.2 - 26.4 |
||
| CD-1 | Liver hepatocellular carcinoma | Liver |
0.9 - 12.9 |
||
| CD-1 | Lung adenocarcinoma | Lung |
2.9 - 20 |
||
| CD-1 | Lung adenoma | Lung |
14.5 - 14.6 |
||
| CD-1 | Mammary gland adenocarcinoma | Mammary gland |
0 - 6.3 |
||
| CD-1 | Mammary gland adenoma | Mammary gland |
0.1 - 1.0 |
||
| CD-1 | Mesodermal cell/mesoblast sarcoma | Uterus - Endometrium |
0.2 |
||
| CD-1 | Mesodermal cell/mesoblast sarcoma - unclassified | Intestine - Small Intestine |
0 - 0.1 |
||
| CD-1 | Mesodermal cell/mesoblast sarcoma - unclassified | Intestine - Large Intestine |
0 - 0.1 |
||
| CD-1 | Mesodermal cell/mesoblast sarcoma - unclassified | Subcutis |
0 - 0.1 |
||
| CD-1 | Mesodermal cell/mesoblast sarcoma - undifferentiated | Adrenal gland |
0.1 - 0.3 |
||
| CD-1 | Mesothelium mesothelioma | Heart |
0 - 0.1 |
||
| CD-1 | Mesothelium mesothelioma - malignant | Abdominal cavity |
0 - 0.1 |
||
| CD-1 | Muscle - Smooth leiomyoma | Oviduct |
0.1 |
||
| CD-1 | Muscle - Smooth leiomyoma | Uterus |
2.4 |
||
| CD-1 | Muscle - Smooth leiomyosarcoma | Subcutis |
0 - 0.1 |
||
| CD-1 | Muscle - Smooth leiomyosarcoma | Uterus |
1.3 |
||
| CD-1 | Muscle - Smooth leiomyosarcoma | Vagina |
0.1 |
||
| CD-1 | Muscle - Striated - Skeletal rhabdomyosarcoma | Subcutis |
0.1 - 0.4 |
||
| CD-1 | Muscle - Striated - Skeletal rhabdomyosarcoma | Abdominal cavity |
0 - 0.1 |
||
| CD-1 | Nose - Nasal cavity squamous cell carcinoma | Nose - Nasal cavity |
0 - 0.1 |
||
| CD-1 | Oral cavity papilloma | Oral cavity |
0 - 0.1 |
||
| CD-1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0.2 |
||
| CD-1 | Ovary - Granulosa cell tumor - malignant | Ovary - Granulosa cell |
0.1 |
||
| CD-1 | Ovary - Theca cell tumor | Ovary - Theca cell |
0.4 |
||
| CD-1 | Ovary adenoma | Ovary |
1.1 |
||
| CD-1 | Ovary luteoma | Ovary |
0.7 |
||
| CD-1 | Ovary papilloma | Ovary |
0.1 |
||
| CD-1 | Oviduct papilloma | Oviduct |
0.1 |
||
| CD-1 | PNS - Schwann cell schwannoma - malignant | Bone - Skull |
0 - 0.1 |
||
| CD-1 | Pancreas - Acinar cell adenoma | Pancreas - Acinar cell |
0 - 0.1 |
||
| CD-1 | Pancreas - Islet of Langerhans adenoma | Pancreas - Islet of Langerhans |
0.3 - 0.6 |
||
| CD-1 | Parathyroid gland adenoma | Parathyroid gland |
0 - 0.1 |
||
| CD-1 | Pituitary gland - Anterior adenocarcinoma | Pituitary gland - Anterior |
0.2 |
||
| CD-1 | Pituitary gland - Anterior adenoma | Pituitary gland - Anterior |
0.2 - 4.7 |
||
| CD-1 | Preputial gland (male) adenoma | Preputial gland (male) |
0.1 |
||
| CD-1 | Prostate gland - Anterior lobe adenoma | Prostate gland - Anterior lobe |
0.3 |
||
| CD-1 | Prostate gland adenoma | Prostate gland |
0.1 |
||
| CD-1 | Salivary gland - Parotid adenoma | Salivary gland - Parotid |
0 - 0.2 |
||
| CD-1 | Salivary gland - Submandibular adenoma | Salivary gland - Submandibular |
0 - 0.2 |
||
| CD-1 | Seminal vesicle adenocarcinoma | Seminal vesicle |
0.1 |
||
| CD-1 | Seminal vesicle adenoma | Seminal vesicle |
0.1 |
||
| CD-1 | Skin - Epidermis - Basal cell carcinoma | Skin - Epidermis - Basal cell |
0 - 0.1 |
||
| CD-1 | Skin keratoacanthoma | Skin |
0.1 |
||
| CD-1 | Skin papilloma | Skin |
0 - 0.2 |
||
| CD-1 | Skin squamous cell carcinoma | Skin |
0.2 - 0.7 |
||
| CD-1 | Stomach - Glandular adenoma | Stomach - Glandular |
0 - 0.1 |
||
| CD-1 | Testis - Leydig cell (Interstitial cell) tumor | Testis - Leydig cell (Interstitial cell) |
0.9 |
||
| CD-1 | Testis - Stroma tumor | Testis - Stroma |
0.1 |
||
| CD-1 | Testis adenoma - papillary | Testis |
0.1 |
||
| CD-1 | Thymus thymoma | Thymus |
0 - 0.1 |
||
| CD-1 | Thyroid gland adenoma | Thyroid gland |
0.7 - 0.9 |
||
| CD-1 | Urinary bladder transitional cell carcinoma | Urinary bladder |
0 - 0.1 |
||
| CD-1 | Uterus adenocarcinoma | Uterus |
0.2 |
||
| CD-1 | Uterus adenoma | Uterus |
0.6 |
||
| CD-1 | Uterus papilloma | Uterus |
0.6 |
||
| CD-1 | (Unspecified organ) histiocytoma - fibrous - malignant | Epididymis |
0.1 |
||
| CD-1 | (Unspecified organ) histiocytoma - fibrous - malignant | Subcutis |
0.3 - 0.4 |