Reference SummaryFrith CH, J Gerontol 1981 Sep;36(5):534-45
Title |
Morphologic classification and correlation of incidence of hyperplastic and neoplastic hematopoietic lesions in mice with age. | ||||||
Authors |
Frith CH; Wiley LD | ||||||
Journal |
J Gerontol | ||||||
Volume |
36 | ||||||
Issue |
5 | ||||||
Year |
1981 | ||||||
Pages |
534-45 | ||||||
Abstract |
Information from the NCTR control pathology data base was examined to morphologically classify and correlate the incidence off hyperplastic and neoplastic hematopoietic lesions with age in over 15,000 male and female mice of a variety of strains. Hyperplasia affected lymphoid and reticular cells, erythropoietic and granulopoietic cells, mast cells, plasma cells and megakaryocytes. Neoplastic lesions included lymphocytic lymphoma, mixed cell lymphoma, histiocytic lymphoma, granulocytic leukemia, plasma cell neoplasms and mast cell neoplasms. Most hyperplastic and neoplastic hematopoietic lesions increased wtih age and most were slightly more common in the female than in the male mice. | ||||||
Links |
J:27153 – MGI References 7264236 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
BALB/cStCrlfC3Hf/Nctr | Erythrocyte hyperplasia | Spleen |
0.37 - 8.3 |
||
C57BL/6JfC3Hf/Nctr | Erythrocyte hyperplasia | Spleen |
0.32 - 6.9 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Erythrocyte hyperplasia | Spleen |
0 - 15.1 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Erythrocyte hyperplasia | Spleen |
0 - 18.7 |
||
C3H | Erythrocyte hyperplasia | Spleen |
1.4 - 15.4 |
||
BALB/cStCrlfC3Hf/Nctr | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell neoplasm | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell |
0 |
||
C57BL/6JfC3Hf/Nctr | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell neoplasm | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell |
0 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell neoplasm | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell |
0 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell neoplasm | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell |
0 |
||
C3H | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell neoplasm | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell |
0 |
||
BALB/cStCrlfC3Hf/Nctr | Leukocyte - Lymphocyte hyperplasia | Lymph node |
0 - 2.8 |
||
BALB/cStCrlfC3Hf/Nctr | Leukocyte - Lymphocyte hyperplasia | Spleen |
0.10 - 10.5 |
||
C57BL/6JfC3Hf/Nctr | Leukocyte - Lymphocyte hyperplasia | Lymph node |
0 - 4.0 |
||
C57BL/6JfC3Hf/Nctr | Leukocyte - Lymphocyte hyperplasia | Spleen |
0 - 5.6 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Leukocyte - Lymphocyte hyperplasia | Lymph node |
0 - 1.6 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Leukocyte - Lymphocyte hyperplasia | Spleen |
0 - 5.9 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Leukocyte - Lymphocyte hyperplasia | Lymph node |
0 - 3.4 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Leukocyte - Lymphocyte hyperplasia | Spleen |
0 - 7.1 |
||
C3H | Leukocyte - Lymphocyte hyperplasia | Lymph node |
0.24 - 0.98 |
||
C3H | Leukocyte - Lymphocyte hyperplasia | Spleen |
0 - 19.9 |
||
BALB/cStCrlfC3Hf/Nctr | Leukocyte - Lymphocyte lymphoma - lymphoblastic | Leukocyte - Lymphocyte |
0.28 - 7.5 |
||
C57BL/6JfC3Hf/Nctr | Leukocyte - Lymphocyte lymphoma - lymphoblastic | Leukocyte - Lymphocyte |
0 - 2.9 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Leukocyte - Lymphocyte lymphoma - lymphoblastic | Leukocyte - Lymphocyte |
0 - 6.8 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Leukocyte - Lymphocyte lymphoma - lymphoblastic | Leukocyte - Lymphocyte |
0 - 7.8 |
||
C3H | Leukocyte - Lymphocyte lymphoma - lymphoblastic | Leukocyte - Lymphocyte |
0 - 1.8 |
||
C57BL/6JfC3Hf/Nctr | Leukocyte - Megakaryocyte hyperplasia | Leukocyte - Megakaryocyte |
0.66 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell hyperplasia | Lymph node |
0.52 |
||
C57BL/6JfC3Hf/Nctr | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell sarcoma - mast cell | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell |
observed |
||
BALB/cStCrlfC3Hf/Nctr | Leukocyte - Myelocyte (Granulocyte) hyperplasia | Spleen |
0 - 8.0 |
||
C57BL/6JfC3Hf/Nctr | Leukocyte - Myelocyte (Granulocyte) hyperplasia | Spleen |
0 - 5.6 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Leukocyte - Myelocyte (Granulocyte) hyperplasia | Spleen |
0 - 4.2 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Leukocyte - Myelocyte (Granulocyte) hyperplasia | Spleen |
0 - 8.3 |
||
C3H | Leukocyte - Myelocyte (Granulocyte) hyperplasia | Spleen |
0 - 2.7 |
||
BALB/cStCrlfC3Hf/Nctr | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 - 0.25 |
||
C57BL/6JfC3Hf/Nctr | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 - 1.6 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 |
||
C3H | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 - 0.30 |
||
BALB/cStCrlfC3Hf/Nctr | Leukocyte lymphoma - histiocytic | Leukocyte |
0 - 0.63 |
||
C57BL/6JfC3Hf/Nctr | Leukocyte lymphoma - histiocytic | Leukocyte |
0 - 4.0 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Leukocyte lymphoma - histiocytic | Leukocyte |
0 - 6.8 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Leukocyte lymphoma - histiocytic | Leukocyte |
0 - 6.7 |
||
C3H | Leukocyte lymphoma - histiocytic | Leukocyte |
0 - 0.91 |
||
BALB/cStCrlfC3Hf/Nctr | Leukocyte lymphoma - mixed | Leukocyte |
0 - 35.0 |
||
C57BL/6JfC3Hf/Nctr | Leukocyte lymphoma - mixed | Leukocyte |
0 - 19.7 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Leukocyte lymphoma - mixed | Leukocyte |
0 - 28.6 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Leukocyte lymphoma - mixed | Leukocyte |
0 - 29.0 |
||
C3H | Leukocyte lymphoma - mixed | Leukocyte |
0 - 7.3 |
||
BALB/cStCrlfC3Hf/Nctr | Reticular cell hyperplasia | Lymph node |
0 - 1.4 |
||
BALB/cStCrlfC3Hf/Nctr | Reticular cell hyperplasia | Spleen |
0.09 - 5.1 |
||
C57BL/6JfC3Hf/Nctr | Reticular cell hyperplasia | Lymph node |
0 - 3.5 |
||
C57BL/6JfC3Hf/Nctr | Reticular cell hyperplasia | Spleen |
0 - 5.1 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Reticular cell hyperplasia | Lymph node |
0 - 2.2 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 | Reticular cell hyperplasia | Spleen |
0 - 4.2 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Reticular cell hyperplasia | Lymph node |
0 - 1.6 |
||
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 | Reticular cell hyperplasia | Spleen |
0 - 2.1 |
||
C3H | Reticular cell hyperplasia | Lymph node |
0 - 0.60 |
||
C3H | Reticular cell hyperplasia | Spleen |
0.24 - 3.6 |