Reference SummaryKurooka M, Cancer Lett 1998 May 15;127(1-2):55-61

Title

 High incidence of esophageal cancer in esophageal achalasia by the oral administration of N-amyl-N-methylnitrosamine and its prevention by nicardipine hydrochloride in mice.

Authors

 Kurooka M; Hongyo T; Nakajima H; Baskar R; Li LY; Fukuda K; Sutoh K; Miyata M; Matsuda H; Nomura T

Journal

 Cancer Lett

Volume

 127

Issue

 1-2

Year

 1998

Pages

 55-61

Abstract

 Esophageal achalasia (EA) is a rare disease in man and animals and there are many discussions on its higher risk of esophageal cancer. N-Amyl-N-methylnitrosamine (AMN) which specifically induces esophageal tumors in mice and rats was given to three mutant mouse strains, i.e. 101/N, STX/Le and BXH-8, which develop a high incidence of EA. The incidence of EA in 101/N, STX/Le, BXH-8 and normal C57BL/6J mice was 38.5% (110/286), 30.1% (43/143), 91.8% (190/207) and 0% (0/167), respectively. The average numbers of AMN-induced esophageal tumors in EA(+) were significantly higher than those of EA(-) in all of the 101/N, STX/Le and BXH-8 mice. Furthermore, significantly larger size tumors and invasive squamous cell carcinomas were found in EA(+) mice than in EA(-) mice. These results indicate the higher sensitivity of EA for both tumor induction and promotion, possibly due to the longer retention of AMN. In fact, relaxation of the lower esophagus by a smooth muscle relaxing calcium-channel blocker, nicardipine hydrochloride, significantly prevented the induction of esophageal tumors.

Links

 J:48901 – MGI References
9619858 – National Library of Medicine/PubMed

Strain Notes

Strain Note
BXH8/TyJ These mice were from The Jackson Laboratory.
C57BL/6J These mice were from Dr. E.S. Russell at the Jackson Laboratory.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
101/N Esophagus squamous cell carcinoma
  • N-amyl-N-methylnitrosoamine (AMN)
 Esophagus

observed
STX/Le Esophagus squamous cell carcinoma
  • N-amyl-N-methylnitrosoamine (AMN)
 Esophagus

observed
BXH8/TyJ Esophagus squamous cell carcinoma
  • N-amyl-N-methylnitrosoamine (AMN)
 Esophagus

observed
C57BL/6J Esophagus squamous cell carcinoma
  • N-amyl-N-methylnitrosoamine (AMN)
 Esophagus

observed
101/N Esophagus tumor Esophagus

0
101/N Esophagus tumor
  • N-amyl-N-methylnitrosoamine (AMN)
 Esophagus

100
STX/Le Esophagus tumor Esophagus

0
STX/Le Esophagus tumor
  • N-amyl-N-methylnitrosoamine (AMN)
 Esophagus

99
BXH8/TyJ Esophagus tumor Esophagus

0
BXH8/TyJ Esophagus tumor
  • N-amyl-N-methylnitrosoamine (AMN)
 Esophagus

100
C57BL/6J Esophagus tumor Esophagus

0
C57BL/6J Esophagus tumor
  • N-amyl-N-methylnitrosoamine (AMN)
 Esophagus

100
BXH8/TyJ Esophagus tumor
  • N-amyl-N-methylnitrosoamine (AMN)
  • nicardipine hydrochloride (Nicardipine)
 Esophagus

100
BXH8/TyJ Esophagus tumor
  • nicardipine hydrochloride (Nicardipine)
 Esophagus

0