Reference SummarySaez E, Nat Med 1998 Sep;4(9):1058-61
Title |
Activators of the nuclear receptor PPARgamma enhance colon polyp formation. |
Authors |
Saez E; Tontonoz P; Nelson MC; Alvarez JG; Ming UT; Baird SM; Thomazy VA; Evans RM |
Journal |
Nat Med |
Volume |
4 |
Issue |
9 |
Year |
1998 |
Pages |
1058-61 |
Abstract |
A high-fat diet increases the risk of colon, breast and prostate cancer. The molecular mechanism by which dietary lipids promote tumorigenesis is unknown. Their effects may be mediated at least in part by the peroxisome proliferator-activated receptors (PPARs). These ligand-activated nuclear receptors modulate gene expression in response to fatty acids, lipid-derived metabolites and antidiabetic drugs. To explore the role of the PPARs in diet-induced carcinogenesis, we treated mice predisposed to intestinal neoplasia with a synthetic PPARgamma ligand. Reflecting the pattern of expression of PPARgamma in the gastrointestinal tract, treated mice developed a considerably greater number of polyps in the colon but not in the small intestine, indicating that PPARgamma activation may provide a molecular link between a high-fat diet and increased risk of colorectal cancer. |
Links |
J:49813 – MGI References 9734400 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon carcinoma |
|
Intestine - Large Intestine - Colon |
observed |
|
| C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon carcinoma | Intestine - Large Intestine - Colon |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
observed |
|
| C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
observed |
|
| C57BL/6J | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
0 |
|
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine polyp |
|
Intestine - Small Intestine |
observed |
|
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine polyp | Intestine - Small Intestine |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine tumor |
|
Intestine - Small Intestine |
observed |