Reference SummaryMaroulakou IG, Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11236-40

Title

 Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene.

Authors

 Maroulakou IG; Anver M; Garrett L; Green JE

Journal

 Proc Natl Acad Sci U S A

Volume

 91

Issue

 23

Year

 1994

Pages

 11236-40

Abstract

 A transgenic mouse model for prostate and mammary cancer has been developed in mice containing a recombinant gene expressing the simian virus 40 early-region transforming sequences under the regulatory control of the rat prostatic steroid binding protein [C3(1)] gene. Male transgenic mice develop prostatic hyperplasia in early life that progresses to adenoma or adenocarcinoma in most animals surviving to longer than 7 months of age. Prostate cancer metastases to lung have been observed. Female animals from the same founder lines generally develop mammary hyperplasia by 3 months of age with subsequent development of mammary adenocarcinoma by 6 months of age in 100% of the animals. The development of tumors correlates with the expression of the transgene as determined by Northern blot and immunohistochemical analyses. The results of these experiments demonstrate that the C3(1) regulatory region used in these experiments is useful for targeting expression to the prostate and mammary gland. To our knowledge, this experimental system is the first reported transgenic mouse model for prostate cancer. These transgenic animals offer the opportunity to study hormone response elements in vivo and the multistage progression from normal tissue to carcinoma in the prostate and mammary glands.

Links

 J:52786 – MGI References
7972041 – National Library of Medicine/PubMed

Strain Notes

Strain Note
FVB/N-Tg(C3-1-TAg)cJeg Expression of the "C3-1-TAg" transgene was reported to not be detected in the brain, kidney, lungs, liver, spleen, and heart of these mice.
Expression of the "C3-1-TAg" transgene was reported to not be detected in the kidney, salivary gland, lungs, liver, muscle, and spleen of these mice.
The "C3-1-TAg" transgene was reported to be expressed in the mammary glands of these mice.
The "C3-1-TAg" transgene was reported to be highly expressed in the salivary gland, and expressed in the prostate gland of these mice. Little or no expression of the transgene was reported to be observed in the testis of these mice.
FVB/N-Tg(C3-1-TAg)lJeg Expression of the "C3-1-TAg" transgene was reported to not be detected in the kidney, brain, heart, lungs, and spleen of these mice.
Expression of the "C3-1-TAg" transgene was reported to not be detected in the muscle, liver, brain, spleen, kidney, and heart of these mice.
The "C3-1-TAg" transgene was reported to be expressed in the mammary glands of these mice. Little or no expression of the transgene was reported to be observed in the lungs of these mice.
The "C3-1-TAg" transgene was reported to be expressed in the prostate gland and salivary glands of these mice. Little or no expression of the transgene was reported to be observed in the testis of these mice.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
FVB/N-Tg(C3-1-TAg)kJeg Bone osteosarcoma Bone

100
FVB/N-Tg(C3-1-TAg)iJeg Bone osteosarcoma Bone

100
FVB/N-Tg(C3-1-TAg)lJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100
FVB/N-Tg(C3-1-TAg)fJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100
FVB/N-Tg(C3-1-TAg)jJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100
FVB/N-Tg(C3-1-TAg)gJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100
FVB/N-Tg(C3-1-TAg)kJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100
FVB/N-Tg(C3-1-TAg)iJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100
FVB/N-Tg(C3-1-TAg)lJeg Eye - Harderian gland hyperplasia Eye - Harderian gland

100
FVB/N-Tg(C3-1-TAg)fJeg Eye - Harderian gland hyperplasia Eye - Harderian gland

100
FVB/N-Tg(C3-1-TAg)jJeg Eye - Harderian gland hyperplasia Eye - Harderian gland

100
FVB/N-Tg(C3-1-TAg)gJeg Eye - Harderian gland hyperplasia Eye - Harderian gland

100
FVB/N-Tg(C3-1-TAg)iJeg Eye - Harderian gland hyperplasia Eye - Harderian gland

100
FVB/N-Tg(C3-1-TAg)lJeg Lung carcinoma Lung

100
FVB/N-Tg(C3-1-TAg)iJeg Lung carcinoma Lung

100
FVB/N-Tg(C3-1-TAg)cJeg Mammary gland adenocarcinoma Mammary gland

100
FVB/N-Tg(C3-1-TAg)lJeg Mammary gland adenocarcinoma Mammary gland

observed - 100
FVB/N-Tg(C3-1-TAg)fJeg Mammary gland adenocarcinoma Mammary gland

100
FVB/N-Tg(C3-1-TAg)#Jeg Mammary gland adenocarcinoma - type B Mammary gland

very high
FVB/N-Tg(C3-1-TAg)#Jeg Mammary gland hyperplasia Mammary gland

67
FVB/N-Tg(C3-1-TAg)lJeg Mammary gland hyperplasia Mammary gland

observed
FVB/N Mammary gland tumor Mammary gland

0
FVB/N-Tg(C3-1-TAg)lJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100
FVB/N-Tg(C3-1-TAg)fJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100
FVB/N-Tg(C3-1-TAg)jJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100
FVB/N-Tg(C3-1-TAg)gJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100
FVB/N-Tg(C3-1-TAg)kJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100
FVB/N-Tg(C3-1-TAg)iJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100
FVB/N-Tg(C3-1-TAg)lJeg Nose - Nasal cavity tumor Nose - Nasal cavity

high
FVB/N-Tg(C3-1-TAg)#Jeg Prostate gland adenocarcinoma Prostate gland

high
FVB/N-Tg(C3-1-TAg)lJeg Prostate gland adenocarcinoma Prostate gland

observed
FVB/N-Tg(C3-1-TAg)cJeg Prostate gland adenocarcinoma Prostate gland

observed
FVB/N-Tg(C3-1-TAg)#Jeg Prostate gland adenoma Prostate gland

33
FVB/N-Tg(C3-1-TAg)kJeg Prostate gland hyperplasia Prostate gland

100
FVB/N-Tg(C3-1-TAg)iJeg Prostate gland hyperplasia Prostate gland

100
FVB/N-Tg(C3-1-TAg)#Jeg Prostate gland hyperplasia Prostate gland

observed
FVB/N-Tg(C3-1-TAg)lJeg Prostate gland hyperplasia Prostate gland

observed
FVB/N-Tg(C3-1-TAg)cJeg Prostate gland hyperplasia Prostate gland

observed
FVB/N Prostate gland tumor Prostate gland

0
FVB/N-Tg(C3-1-TAg)lJeg Salivary gland lesion Salivary gland

100
FVB/N-Tg(C3-1-TAg)fJeg Salivary gland lesion Salivary gland

100
FVB/N-Tg(C3-1-TAg)jJeg Salivary gland lesion Salivary gland

100
FVB/N-Tg(C3-1-TAg)gJeg Salivary gland lesion Salivary gland

100
FVB/N-Tg(C3-1-TAg)kJeg Salivary gland lesion Salivary gland

100
FVB/N-Tg(C3-1-TAg)iJeg Salivary gland lesion Salivary gland

100
FVB/N-Tg(C3-1-TAg)gJeg Thyroid gland adenoma Thyroid gland

100
FVB/N-Tg(C3-1-TAg)fJeg Thyroid gland carcinoma Thyroid gland

100
FVB/N-Tg(C3-1-TAg)jJeg Thyroid gland hyperplasia Thyroid gland

100
FVB/N-Tg(C3-1-TAg)iJeg Thyroid gland hyperplasia Thyroid gland

100