Reference SummaryPodsypanina K, Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1563-8
Title |
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. | ||||
Authors |
Podsypanina K; Ellenson LH; Nemes A; Gu J; Tamura M; Yamada KM ; Cordon-Cardo C ; Catoretti G ; Fisher PE ; Parsons R | ||||
Journal |
Proc Natl Acad Sci U S A | ||||
Volume |
96 | ||||
Issue |
4 | ||||
Year |
1999 | ||||
Pages |
1563-8 | ||||
Abstract |
Pten/Mmac1 +/- heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was detected in neoplasms of the thymus and liver. Surprisingly, tumors of the gastrointestinal epithelium developed in association with gut lymphoid tissue. Tumors of the endometrium, thyroid, prostate, and liver were not associated with lymphoid tissue and appeared to be highly mitotic. In addition, these mice have nonneoplastic hyperplasia of lymph nodes that was caused by an inherited defect in apoptosis detected in B cells and macrophages. Examination of peripheral lymphoid tissue including lymphoid aggregates associated with polyps revealed that the normal organization of B and T cells was disrupted in heterozygous animals. Taken together, these data suggest that PTEN is a regulator of apoptosis and proliferation that behaves as a ''landscaper'' tumor suppressor in the gut and a ''gatekeeper'' tumor suppressor in other organs. | ||||
Links |
J:53065 – MGI References 9990064 – National Library of Medicine/PubMed |
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Strain Notes
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| B6;129S1-Ptentm1Rps/+ | CNS - Brain tumor | CNS - Brain |
0 |
||
| B6;129S1-Ptentm1Rps/+ | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
1.2 |
||
| C57BL/6J +/+ : 129S1/Sv p+ Tyr+ Kitl+ Ptentm1Rps/+ | Intestine - Large Intestine polyp | Intestine - Large Intestine |
89 |
||
| C57BL/6J +/+ : 129S1/Sv p+ Tyr+ Kitl+ Ptentm1Rps/+ | Intestine - Small Intestine polyp | Intestine - Small Intestine |
89 |
||
| B6;129S1-Ptentm1Rps/+ | Intestine polyp | Intestine |
100 |
||
| B6;129S1 | Intestine polyp | Intestine |
0 |
||
| C57BL/6J | Intestine polyp | Intestine |
0 |
||
| B6;129S1-Ptentm1Rps/+ | Leukocyte - Lymphoblast lymphoma | Leukocyte - Lymphoblast |
2.7 |
||
| B6;129S1-Ptentm1Rps/+ | Leukocyte - Lymphoblast lymphoma | Kidney |
observed |
||
| B6;129S1-Ptentm1Rps/+ | Leukocyte leukemia | Leukocyte |
0.4 |
||
| B6;129S1-Ptentm1Rps/+ | Liver adenoma | Liver |
0.4 |
||
| B6;129S1-Ptentm1Rps/+ | Lymph node hyperplasia | Lymph node |
73 |
||
| B6;129S1-Ptentm1Rps/+ | Mammary gland neoplasia | Mammary gland |
0 |
||
| B6;129S1-Ptentm1Rps/+ | Ovary - Germ cell teratoma | Uterus |
0.4 |
||
| B6;129S1-Ptentm1Rps/+ | Prostate gland hyperplasia | Prostate gland |
38 |
||
| B6;129S1-Ptentm1Rps/+ | Prostate gland prostatic intraepithelial neoplasia (PIN) | Prostate gland |
38 |
||
| B6;129S1-Ptentm1Rps/+ | Skin neoplasia | Skin |
0 |
||
| C57BL/6J +/+ : 129S1/Sv p+ Tyr+ Kitl+ Ptentm1Rps/+ | Testis - Germ cell teratoma | Testis - Germ cell |
11 |
||
| B6;129S1-Ptentm1Rps/+ | Testis tumor | Testis |
0 |
||
| B6;129S1-Ptentm1Rps/+ | Thyroid gland - Follicular cell neoplasia | Thyroid gland - Follicular cell |
15 |
||
| B6;129S1-Ptentm1Rps/+ | Thyroid gland carcinoma | Thyroid gland |
0.4 |
||
| B6;129S1 | Thyroid gland neoplasia | Thyroid gland |
0 |
||
| B6;129S1-Ptentm1Rps/+ | Uterus - Endometrium hyperplasia | Uterus - Endometrium |
100 |
||
| B6;129S1 | Uterus - Endometrium hyperplasia | Uterus - Endometrium |
observed - 8.3 |