Reference SummaryKondo Y, Carcinogenesis 1999 Aug;20(8):1625-7

Title

Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine in mice.

Authors

Kondo Y; Himeno S; Endo W; Mita M; Suzuki Y; Nemoto K; Akimoto M; Lazo JS; Imura N

Journal

Carcinogenesis

Volume

20

Issue

8

Year

1999

Pages

1625-7

Abstract

We examined the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in transgenic mice deficient in the metallothionein (MT) I and II genes and in control (129/Sv) mice. Both strains of mice were given BBN for 8 weeks with or without Zn treatment. All mice were killed at 12 weeks after the cessation of BBN administration. BBN induced bladder tumors in 75% of MT null mice and in 43% of 129/Sv mice. The average number of bladder tumors per mouse was significantly higher in MT null mice (1. 18 +/- 0.27) than in 129/Sv mice (0.43 +/- 0.20). Zn treatment suppressed the carcinogenicity of BBN in 129/Sv mice but not in MT null mice. Histopathological examination of the tumors revealed that the malignant potential of bladder tumors in 129/Sv mice was greater than that in MT null mice. These results indicate that MT is an important modulator of carcinogenicity of BBN in the bladder of mice.

Links

10426817 – National Library of Medicine/PubMed
J:56770 – MGI References

Strain Notes

Strain Note
129S1/SvImJ These mice were purchased from the Jackson Laboratory.
129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J These mice were from The Jackson Laboratory.

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
129S1/SvImJ Urinary bladder transitional cell carcinoma
  • N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)
Urinary bladder

43

129S1/SvImJ Urinary bladder transitional cell carcinoma
  • ZnCl2
  • N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)
Urinary bladder

20

129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J Urinary bladder transitional cell carcinoma
  • N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)
Urinary bladder

75

129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J Urinary bladder transitional cell carcinoma
  • ZnCl2
  • N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)
Urinary bladder

73

129S1/SvImJ Urinary bladder tumor Urinary bladder

0

129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J Urinary bladder tumor Urinary bladder

0