Reference SummaryKondo Y, Carcinogenesis 1999 Aug;20(8):1625-7
Title |
Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine in mice. | ||||||
Authors |
Kondo Y; Himeno S; Endo W; Mita M; Suzuki Y; Nemoto K; Akimoto M; Lazo JS; Imura N | ||||||
Journal |
Carcinogenesis | ||||||
Volume |
20 | ||||||
Issue |
8 | ||||||
Year |
1999 | ||||||
Pages |
1625-7 | ||||||
Abstract |
We examined the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in transgenic mice deficient in the metallothionein (MT) I and II genes and in control (129/Sv) mice. Both strains of mice were given BBN for 8 weeks with or without Zn treatment. All mice were killed at 12 weeks after the cessation of BBN administration. BBN induced bladder tumors in 75% of MT null mice and in 43% of 129/Sv mice. The average number of bladder tumors per mouse was significantly higher in MT null mice (1. 18 +/- 0.27) than in 129/Sv mice (0.43 +/- 0.20). Zn treatment suppressed the carcinogenicity of BBN in 129/Sv mice but not in MT null mice. Histopathological examination of the tumors revealed that the malignant potential of bladder tumors in 129/Sv mice was greater than that in MT null mice. These results indicate that MT is an important modulator of carcinogenicity of BBN in the bladder of mice. | ||||||
Links |
10426817 – National Library of Medicine/PubMed J:56770 – MGI References |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
129S1/SvImJ | Urinary bladder transitional cell carcinoma |
|
Urinary bladder |
43 |
|
129S1/SvImJ | Urinary bladder transitional cell carcinoma |
|
Urinary bladder |
20 |
|
129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J | Urinary bladder transitional cell carcinoma |
|
Urinary bladder |
75 |
|
129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J | Urinary bladder transitional cell carcinoma |
|
Urinary bladder |
73 |
|
129S1/SvImJ | Urinary bladder tumor | Urinary bladder |
0 |
||
129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J | Urinary bladder tumor | Urinary bladder |
0 |