Reference SummaryFlemming A, Nat Immunol 2003 Jan;4(1):38-43

Title

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

Authors

Flemming A; Brummer T; Reth M; Jumaa H

Journal

Nat Immunol

Volume

4

Issue

1

Year

2003

Pages

38-43

Abstract

Mice deficient in the adaptor protein SLP-65 (also known as BLNK) have reduced numbers of mature B cells, but an increased pre-B cell compartment. We show here that compared to wild-type cells, SLP-65(-/-) pre-B cells show an enhanced ex vivo proliferative capacity. This proliferation requires interleukin 7 and expression of the pre-B cell receptor (pre-BCR). In addition, SLP-65(-/-) mice have a high incidence of pre-B cell lymphoma. Reintroduction of SLP-65 into SLP-65(-/-) pre-B cells led to pre-BCR down-regulation and enhanced differentiation. Our results indicate that SLP-65 regulates a developmental program that promotes differentiation and limits pre-B cell expansion, thereby acting as a tumor suppressor.

Links

J:80332 – MGI References
12436112 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
BALB/c Leukocyte - Lymphocyte - Pre-B-lymphocyte hyperplasia Leukocyte - Lymphocyte - Pre-B-lymphocyte

0

[not specified]-Blnktm1Pjln Leukocyte - Lymphocyte - Pre-B-lymphocyte hyperplasia Leukocyte - Lymphocyte - Pre-B-lymphocyte

9.5

BALB/c Leukocyte - Lymphocyte - Pre-B-lymphocyte tumor Leukocyte - Lymphocyte - Pre-B-lymphocyte

0.05

[not specified]-Blnktm1Pjln Leukocyte - Lymphocyte - Pre-B-lymphocyte tumor Leukocyte - Lymphocyte - Pre-B-lymphocyte

6.7