Reference SummaryLacroix-Triki M, Toxicol Pathol 2003 May-Jun;31(3):304-9
Title |
Histiocytic Sarcoma in C57BL/6J Female Mice is Associated with Liver Hematopoiesis: Review of 41 Cases. | ||||
Authors |
Lacroix-Triki M; Lacoste-Collin L; Jozan S; Charlet JP; Caratero C; Courtade M | ||||
Journal |
Toxicol Pathol | ||||
Volume |
31 | ||||
Issue |
3 | ||||
Year |
2003 | ||||
Pages |
304-9 | ||||
Abstract |
Forty-one cases of histiocytic sarcoma (HS) in C57BL/6J mice were histopathologically studied with special regard to unexpected associated hematopoietic disorders. These cases were retrieved among C57BL/6J female mice used as control mice in a chronic low-dose irradiation experiment. Hematopoietic characteristics were analysed by comparison to 41 disease-free mice from the same cohort. Tumoral involvement of the liver was observed in all 41 HS-bearing mice, followed by infiltration of the spleen (61.8%), lung (32.4%), bone marrow (14.3%), uterus (12.2%), lymph node (9.8%), and kidney (2.4%). By comparative analysis, we were able to demonstrate a significant association of HS with liver hematopoiesis (89.5% in HS group vs 15% in control mice, p < 0.00001), and with central hematopoietic disorders involving the myelocytic cells (decreased in HS, p = 0.003) and erythrocytic cells (increased in HS, p = 0.001). Microscopic characteristics of these 41 cases and physiopathology of the newly described hematopoietic features in HS are further discussed. | ||||
Links |
J:84222 – MGI References 12746118 – National Library of Medicine/PubMed |
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Strain Notes
|
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6JIco | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Liver |
13 |
||
| C57BL/6JIco | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Spleen |
6.5 |
||
| C57BL/6JIco | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Uterus |
1.5 |
||
| C57BL/6JIco | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
13 |