Reference SummaryPicut CA, Exp Toxicol Pathol 2003 Jul;55(1):1-9

Title

 Bromoethane, chloroethane and ethylene oxide induced uterine neoplasms in B6C3F1 mice from 2-year NTP inhalation bioassays: pathology and incidence data revisited.

Authors

 Picut CA; Aoyama H; Holder JW; Gold LS; Maronpot RR; Dixon D

Journal

 Exp Toxicol Pathol

Volume

 55

Issue

 1

Year

 2003

Pages

 1-9

Abstract

 Chloroethane, bromoethane and ethylene oxide represent a unique set of chemicals that induce endometrial neoplasms in the uterus of B6C3F1 mice following an inhalation route of exposure. The results of the NTP's chronic bioassays with these three compounds resulted in an unusually high incidence of uterine epithelial neoplasms in B6C3F1 mice (chloroethane 86%, bromoethane 56%) and a lower incidence for ethylene oxide (10%). The uterine neoplasms were classified as adenomas, adenocarcinomas, and squamous cell carcinomas for bromoethane, and as adenocarcinomas for both chloroethane and ethylene oxide. The adenocarcinomas and squamous cell carcinomas were invasive into the myometrium and the serosa, and metastasized to a wide variety of organs. Metastatic sites included most commonly the lung, lymph nodes, and ovary at unusually high rates of metastases (79% for chloroethane and 38% for bromoethane). Because of the dramatically high rates of uterine neoplasms (induced by chemicals given by the inhalation route) and metastases, a re-evaluation of the pathology and incidence data was undertaken. The earlier results were confirmed. The mechanism of uterine carcinogenesis by chloroethane, bromoethane and ethylene oxide is unclear.

Links

 J:85683 – MGI References
12940622 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
(C57BL/6 x C3H)F1 Eye - Harderian gland neoplasm - benign
  • ethylene oxide
 Eye - Harderian gland

observed
(C57BL/6 x C3H)F1 Lung neoplasm - malignant
  • ethylene oxide
 Lung

observed
(C57BL/6 x C3H)F1 Mammary gland neoplasm - malignant
  • ethylene oxide
 Mammary gland

0 - observed
(C57BL/6 x C3H)F1 Uterus - Endometrium adenocarcinoma
  • Chloroethane
 Uterus - Endometrium

86
(C57BL/6 x C3H)F1 Uterus - Endometrium adenocarcinoma Uterus - Endometrium

0
(C57BL/6 x C3H)F1 Uterus - Endometrium neoplasm Uterus - Endometrium

0
(C57BL/6 x C3H)F1 Uterus - Endometrium neoplasm
  • bromoethane (ethyl bromide)
 Uterus - Endometrium

8 - 56.25
(C57BL/6 x C3H)F1 Uterus adenocarcinoma Uterus

0
(C57BL/6 x C3H)F1 Uterus adenocarcinoma
  • bromoethane (ethyl bromide)
 Uterus

4 - 39.58
(C57BL/6 x C3H)F1 Uterus adenocarcinoma
  • Chloroethane
 Uterus

86
(C57BL/6 x C3H)F1 Uterus adenocarcinoma
  • ethylene oxide
 Uterus

0 - 10.2
(C57BL/6 x C3H)F1 Uterus adenocarcinoma - anaplastic
  • bromoethane (ethyl bromide)
 Uterus

observed
(C57BL/6 x C3H)F1 Uterus adenocarcinoma - glandular
  • ethylene oxide
 Uterus

0 - 10.2
(C57BL/6 x C3H)F1 Uterus adenocarcinoma - squamous
  • Chloroethane
 Uterus

observed
(C57BL/6 x C3H)F1 Uterus adenocarcinoma - squamous
  • ethylene oxide
 Uterus

2.04
(C57BL/6 x C3H)F1 Uterus adenoma Uterus

0
(C57BL/6 x C3H)F1 Uterus adenoma
  • bromoethane (ethyl bromide)
 Uterus

2 - 12.5
(C57BL/6 x C3H)F1 Uterus neoplasm
  • bromoethane (ethyl bromide)
 Uterus

observed
(C57BL/6 x C3H)F1 Uterus neoplasm
  • ethylene oxide
 Uterus

2.04
(C57BL/6 x C3H)F1 Uterus neoplasm - epithelial Uterus

0
(C57BL/6 x C3H)F1 Uterus neoplasm - epithelial
  • bromoethane (ethyl bromide)
 Uterus

8 - 56.25
(C57BL/6 x C3H)F1 Uterus squamous cell carcinoma Uterus

0
(C57BL/6 x C3H)F1 Uterus squamous cell carcinoma
  • bromoethane (ethyl bromide)
 Uterus

2 - 6.25
(C57BL/6 x C3H)F1 Uterus tumor
  • bromoethane (ethyl bromide)
 Uterus

observed - 56.25
(C57BL/6 x C3H)F1 Uterus tumor Uterus

0
(C57BL/6 x C3H)F1 Uterus tumor - endothelial Uterus

0
(C57BL/6 x C3H)F1 Uterus tumor - epithelial
  • Chloroethane
 Uterus

86
(C57BL/6 x C3H)F1 Uterus tumor - epithelial
  • ethylene oxide
 Uterus

0 - 10.2
(C57BL/6 x C3H)F1 (Unspecified organ) neoplasm - malignant
  • ethylene oxide
 (Unspecified organ)

0 - observed
(C57BL/6 x C3H)F1 (Unspecified organ) tumor (Unspecified organ)

0
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • Chloroethane
 (Unspecified organ)

0 - observed
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • bromoethane (ethyl bromide)
 (Unspecified organ)

0 - observed
(C57BL/6 x C3H)F1 (Unspecified organ) tumor
  • ethylene oxide
 (Unspecified organ)

observed