Lung Cancer Model: TM00194

NSG™ mice engrafted with passage 4 tumors for model TM00194 were randomly assigned to one of these treatment groups:

• 5% dextrose in water (vehicle control; 5 ml/kg; IV once per week for three times; N=8-10)
• Cisplatin (2 mg/kg; IV once per week for three times; N=8-10)
• Etoposide (15 mg/kg; IP twice per week for three cycles; N=8-10)
• Topotecan (2 mg/kg; PO once daily for 5 days for three cycles; N=8-10)
• Cisplatin + Etoposide combination (2 mg/kg; IV once per week for two times + 15 mg/kg; IP twice per week for 2 cycles; N=8-10)

Mice were monitored for tumor volume at least twice per week throughout the study period.

• Treatment groups     • Individual subjects / spider plot     • RECIST scores     • Waterfall plot     • TGI plot         • Protocols