Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-06-16
MTB 3.0
 
Welcome to the Mouse Tumor Biology (MTB) Database

The Mouse Tumor Biology (MTB) Database supports the use of the mouse as a model system of human cancers by providing access to information on and data for:

  • spontaneous and induced tumors in mice,
  • genetically defined mice (inbred, hybrid, mutant, and genetically engineered strains of mice) in which tumors arise,
  • genetic factors associated with tumor susceptibility in mice,
  • somatic genetic-mutations observed in tumors,
  • Patient Derived Xenograft (PDX) models

Examples of the data accessible from MTB include:

  • tumor frequency & latency data,
  • tumor genomic data,
  • tumor pathology reports and images,
  • associations of models to the scientific literature,
  • links additional on-line cancer resources




 
Cancer Site
Mouse Models of Human Cancer
(restricted to reports where
n≥20 mice and tumor frequency≥80%)
All
Strains





[1]
158,770
47
114
161
78
[2]
58,100
130
35
165
45
[3]
53,240
64
4
68
87
[4]
44,330
18
0
18
16
[5]
41,400
118
31
149
44
[6]
30,200
21
13
34
3
[7]
29,430
47
0
47
2
[8]
17,240
7
1
8
28
[9]
16,830
40
0
40
25
[10]
15,850
0
5
5
0
[11]
15,520
4
0
4
4
[12]
14,970
5
0
5
9
[13]
14,070
9
0
9
12
[14]
13,460
23
11
34
20
[15]
10,800
14
6
20
1
[16]
10,030
3
1
4
3
[17]
5,150
24
19
43
26
[18]
3,790
2
0
2
0
[19]
3,080
58
2
60
1
[20]
1,590
3
0
3
10


What's new in MTB?

2019

  • April
    • MMHCdb (formerly MTB) presented posters at the following:
       AACR Annual Meeting 2019, 29 March - 3 April, Atlanta, Georgia
       Biocuration 2019, 6-10 April, Cambridge, UK (Poster published on F1000)
  • March
    • PDX models can be searched for by tumor mutation burden (TMB).
    • PDX Like Me provides the ability to search for PDX models by molecular profile.
  • January
    • MTB now holds over 95,000 tumor frequency records.

2018

  • April
    • EMBL-EBI and The Jackson Laboratory announce the release of PDXFinder. A comprehensive open global catalog of PDX models and their associated data across resources.

2017

  • December
    • In 2017 MTB presented at the following:
       16th Annual Workshop on the Pathology of Mouse Models for Human Disease, 1-6 October
       Advances in Modeling Cancer in Mice: Technology, Biology & Beyond, 24-27 September
       AACR Annual Meeting 2017, 1-5 April
  • July
    • Interactive plots for dosing studies are now available for PDX models. Four different plot types are provided (treatment group, spider, waterfall, and tumor growth inhibition). A list of all models with dosing study results can be found here. The FAQ on experimental design for dosing studies can be found here.
  • February
    • The new interactive cancer models summary table on the MTB home page lists counts of all of the models in the database for the most common types of human cancer. The links in the models summary table return PDX models or a faceted search summary that users can use to narrow or expand search criteria.

2016

  • December
    • MTB now holds over 80,000 tumor frequency records.
  • April
    • Researchers can now iteratively search MTB for mouse models of human cancer using multiple faceted filter lists with the new Faceted Tumor Search form.
  • March
    • MTB will be presenting posters at the 9th International Biocuration Conference, April 10-14, Geneva, Switzerland and at the AACR Annual Meeting 2016, April 16-20, New Orleans, Louisiana. Stop by and see what's new.

2015

  • December
    • MTB has an article in the December 2015 issue of Experimental and Molecular Pathology. Begley DA, Sundberg JP, Krupke DM, Neuhauser SB, Bult CJ, Eppig JT, Morse HC 3rd, Ward JM. Finding mouse models of human lymphomas and leukemias using the Jackson Laboratory Mouse Tumor Biology database. Exp Mol Pathol. 2015 Dec;99(3):533-6.
  • September
    • MTB now holds over 70,000 tumor frequency records.
  • August
    • 50 Lymphoma and Leukemia Histology and Immunohistochemistry Whole Slide Scans with Detailed Pathology Annotations are now available on the Lymphoma Pathology Page.
  • July
    • The JAX Patient Derived Xenograft (PDX) Resource has information on over 400 PDX models.

2014

  • November
    • MTB is presenting a poster at Beyond the Genome: Cancer Genomics, October 8-10, 2014, Boston, MA.
  • October
    • MTB is highlighted in a publication in Experimental Dermatology:
      Begley DA, Krupke DM, Neuhauser SB, Richardson JE, Schofield PN, Bult CJ, Eppig JT, Sundberg JP. 2014. Identifying mouse models for skin cancer using the Mouse Tumor Biology Database. Exp Dermatol. 2014 Oct; 23(10):761-3. PMID:25040013
  • April
    • MTB now holds over 60,000 tumor frequency records.

2013

  • October
    • Researchers can now search MTB for xenograft models and associated data (histology and genomics) contained in the JAX Patient Derived Xenograft (PDX) Resource.

2012

  • December
    • In 2012 MTB presented at the following:
       11th Annual Workshop on the Pathology of Mouse Models for Human Disease,
       Biocuration 2012,
       Mechanisms & Models of Cancer,
       Model Organisms to Human Biology - Cancer Genetics,
       Second Annual Mutant Mouse Necropsy Workshop.
  • September
    • MTB now holds over 50,000 tumor frequency records.
  • July
    • MTB was highlighted in Chapter 3.1 of 'The Laboratory Mouse, 2nd Edition'.

2011

  • October
    • MTB now holds over 5,000 images, including histopathology, SKY CGH and FISH images.
  • February
    • The immunohistochemistry links have been updated and expanded.

2010

  • November
    • Now you can search for cancer-related mouse gene expression data sets that are in NCBI's Gene Expression Omnibus (GEO) archives with the new Gene Expression Data Set Search Form. Users can search by organ, tumor classification, mouse strain or expression assay platform to find relevant gene expression data sets. Search results provide links to external gene expression data as well as MTB tumor frequency records and strain details.
  • October
    • MTB now holds over 40,000 tumor frequency records
  • April
    • You can now search MTB using Human Gene Symbols. Entering all or part of one or more human gene symbols or Entrez Gene Ids into the new Human Gene Search Form returns orthologous mouse symbols and any genetic data attached to these symbols. These data include alleles and transgenes in mouse strains and tumor specific mutations associated with these symbols. Links allow users to view detailed tumor frequency, strain and pathology data. The search page also includes collections of cancer specific human genes reported by various sources which can be used for orthology searches.
  • January
    • The Tumor Frequency Grid, MTB's interactive graphic display of tumor frequencies, displays as a matrix the strain in which tumors were assessed and the organ systems in which tumors were observed. Our newest enhancements to the Grid allow the user to customize the Grid contents on both axes. Thus, the user can select specific strains or strain families and specific organs or organ systems to obtain a Grid showing any desired combination of strains/families and organs/systems. Try these new enhancements here: http://tumor.informatics.jax.org/mtbwi/dynamicGrid.do

2009

  • September
    • MTB was well represented at the 8th Annual Workshop on the Pathology of Mouse Models for Human Disease, September 11-17, 2009 in Bar Harbor, ME. Participation included a platform presentation by Dr. J.P. Sundberg, entitled "Strain specific diseases in mice: Utilizing online resources" and a tutorial / workshop on using MTB and a poster presentation by Dr. D.A. Begley.

2008

  • December
    • MTB has begun adding cytogenetic assay image data to the image archives. This includes images from spectral karyotyping (SKY), comparative genome hybridization (CGH) and fluorescence in-situ hybridization (FISH) assays of mouse tumors. Users may now refine their genetics searches to only those cytogenetic data associated with an image. Links to cytogenetics image data are also provided in the Genetics section of the Tumor Frequency Details pages (where applicable) (For an example see: http://tumor.informatics.jax.org/mtbwi/assayImageDetails.do?key=7&page=pathology
  • October
    • The Genetics Search Form has been updated and streamlined. Users can search for germline genetic, tumor somatic genetic and, now, cytogenetic data.
  • January
    • MTB now holds over 30,000 tumor frequency records!

2007

  • October
    • MTB announces the incorporation of tumor pathology data and images from the Shock/Ellison Aging Study conducted at the Jackson Aging Center. These images are from young, middle-aged and old mice (male and female) from each of 32 strains. Additional data from this on-going study will be added as it is produced.
  • August
    • MTB is presenting a poster at the Mechanisms & Models of Cancer Meeting, Aug 8 - 12, 2007 at the Salk Institute, La Jolla, California. Stop by and see us!

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