Mouse Models of Human Cancer Database (MMHCdb)

MMHCdb is a comprehensive, expertly curated resource of diverse mouse models of human cancer.

We focus on:

Top Mouse Models of Human Cancer

American Cancer Society Facts & Figures 2022 Mouse Models
Cancer Site Mortality Rank Estimated deaths USA Mutant Strains Other Strains All Strains PDX Models
Lung & other respiratory [1] 135,360 56 116 172 79
Lymphohematopoietic [2] 57,810 133 35 168 22
Colon & other intestine [3] 56,210 76 4 80 81
Pancreas [4] 49,830 26 1 27 15
Breast [5] 43,780 129 31 160 45
Prostate [6] 34,500 50 0 50 2
Liver & bile duct [7] 30,520 23 24 47 2
Brain & other nervous system [8] 18,280 41 0 41 26
Urinary bladder [9] 17,100 7 1 8 27
Uterus & cervix [10] 16,830 6 3 9 6
Esophagus [11] 16,410 0 8 8 0
Kidney & renal pelvis [12] 13,920 5 0 5 8
Ovary [13] 12,810 9 0 9 12
Skin [14] 11,990 23 13 36 20
Oral cavity & pharynx [15] 11,230 3 3 6 3
Stomach [16] 11,090 17 7 24 1
Soft tissue including heart [17] 5,130 27 20 47 26
Gallbladder & other biliary [18] 4,400 2 0 2 0
Endocrine system [19] 3,330 64 2 66 1
Bones & joints [20] 2,100 5 0 5 11

News & Events

  • MMHCdb now contains over 110,000 tumor frequency records! (April 2022)
  • MMHCdb will present a poster at the AACR annual meeting, April 8-13, 2022, New Orleans.
  • MMHCdb is featured as the primary repository for data from The Jackson Laboratory's lung cancer PDX resource published in bioRxiv (Woo, X.Y., et al.) A Genomically and Clinically Annotated Patient Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer. Data about the models in this resource are also accessible from PDX Finder. (March 2022)
  • MMHCdb is highlighted in Chapter 2 of Pathology of genetically engineered mice and other mutants. Sundberg JP, Vogel P, and Ward JM, eds., Wiley. Begley D, Schofield PN, Sundberg JP. The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research. (2022) 6-21.
  • MMHCdb presented at the 19th Annual Workshop on the Pathology of Mouse Models for Human Disease, "Mouse Genome Informatics (MGI) and Mouse Models of Human Cancer Databases". (September 2021)
  • The MMHCdb web site has been updated to provide a new look, consolidate search forms, streamline searching, and introduce new functionality. A new advanced search form has been released which consolidates multiple search forms into a single interface and uses faceted searches to enable users to customize searches and iteratively increase search specificity. The web site layout has been redesigned to be more user friendly and improve data visibility. (September 2020)
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