Mouse Models of Human Cancer Database (MMHCdb)

MMHCdb is a comprehensive, expertly curated resource of diverse mouse models of human cancer.

We focus on:

Top Mouse Models of Human Cancer

American Cancer Society Facts & Figures 2020 Mouse Models
Cancer Site Mortality Rank Estimated deaths USA Mutant Strains Other Strains All Strains PDX Models
Lung & other respiratory [1] 140,730 56 116 172 81
Lymphohematopoietic [2] 56,840 132 35 167 46
Colon & other intestine [3] 56,250 72 4 76 81
Pancreas [4] 47,050 26 1 27 16
Breast [5] 42,690 125 31 156 44
Prostate [6] 33,330 50 0 50 2
Liver & bile duct [7] 30,160 22 24 46 2
Brain & other nervous system [8] 18,020 41 0 41 26
Urinary bladder [9] 17,980 7 1 8 27
Uterus & cervix [10] 16,880 6 3 9 6
Esophagus [11] 16,170 0 8 8 0
Kidney & renal pelvis [12] 14,830 5 0 5 8
Ovary [13] 13,940 9 0 9 12
Skin [14] 11,480 23 13 36 20
Stomach [15] 11,010 17 7 24 1
Oral cavity & pharynx [16] 10,750 3 3 6 3
Soft tissue including heart [17] 5,350 25 20 45 26
Gallbladder & other biliary [18] 4,090 2 0 2 0
Endocrine system [19] 3,260 64 2 66 1
Bones & joints [20] 1,720 5 0 5 11

News & Events

  • The MMHCdb web site has been updated to provide a new look, consolidate search forms, streamline searching, and introduce new functionality. A new advanced search form has been released which consolidates multiple search forms into a single interface and uses faceted searches to enable users to customize searches and iteratively increase search specificity. The web site layout has been redesigned to be more user friendly and improve data visibility. (September 2020)
  • MMHCdb now contains over 9,000 histopathology images including over 2,700 histopathology images for PDX models. (September 2020)
  • MMHCdb presented a virtual poster at the AACR annual meeting, April 24-29, 2020
  • MMHCdb (formerly MTB) now holds over 100,000 tumor frequency records! (December 2019)
  • MMHC is presenting at the 18th Annual Workshop on the Pathology of Mouse Models for Human Disease, Bar Harbor (September 2019)
  • The genome data analysis methods used for mutation, expression, and copy number data associated with Patient Derived Xenograft models generated by The Jackson Laboratory has been published in BMC Medical Genomics: Woo XY, Srivastava A, Graber JH, et al: Genomic data analysis workflows for tumors from patient-derived xenografts (PDXs): challenges and guidelines. BMC Medical Genomics volume 12, Article number: 92 (2019). PDX models and their associated data are searchable from the PDX Search Form and from PDX Finder. (July 2019)
  • View the MMHCdb Biocuration 2019 poster: https://doi.org/10.7490/f1000research.1116709.1 (May 2019)
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