Mouse Models of Human Cancer Database (MMHCdb)

MMHCdb is a comprehensive, expertly curated resource of diverse mouse models of human cancer.

We focus on:

Top Mouse Models of Human Cancer

American Cancer Society Facts & Figures 2021 Mouse Models
Cancer Site Mortality Rank Estimated deaths USA Mutant Strains Other Strains All Strains PDX Models
Lung & other respiratory [1] 137,040 56 116 172 80
Lymphohematopoietic [2] 57,750 133 35 168 46
Colon & other intestine [3] 56,510 74 4 78 81
Pancreas [4] 48,220 26 1 27 15
Breast [5] 44,130 127 31 158 44
Prostate [6] 34,130 50 0 50 2
Liver & bile duct [7] 30,230 23 24 47 2
Brain & other nervous system [8] 18,600 41 0 41 26
Uterus & cervix [9] 17,230 6 3 9 6
Urinary bladder [10] 17,200 7 1 8 27
Esophagus [11] 15,530 0 8 8 0
Kidney & renal pelvis [12] 13,780 5 0 5 8
Ovary [13] 13,770 9 0 9 12
Skin [14] 11,540 23 13 36 20
Stomach [15] 11,180 17 7 24 1
Oral cavity & pharynx [16] 10,850 3 3 6 3
Soft tissue including heart [17] 5,350 26 20 46 26
Gallbladder & other biliary [18] 4,310 2 0 2 0
Endocrine system [19] 3,290 64 2 66 1
Bones & joints [20] 2,060 5 0 5 11

News & Events

  • The MMHCdb web site has been updated to provide a new look, consolidate search forms, streamline searching, and introduce new functionality. A new advanced search form has been released which consolidates multiple search forms into a single interface and uses faceted searches to enable users to customize searches and iteratively increase search specificity. The web site layout has been redesigned to be more user friendly and improve data visibility. (September 2020)
  • MMHCdb now contains over 9,000 histopathology images including over 2,700 histopathology images for PDX models. (September 2020)
  • MMHCdb presented a virtual poster at the AACR annual meeting, April 24-29, 2020
  • MMHCdb (formerly MTB) now holds over 100,000 tumor frequency records! (December 2019)
  • MMHC is presenting at the 18th Annual Workshop on the Pathology of Mouse Models for Human Disease, Bar Harbor (September 2019)
  • The genome data analysis methods used for mutation, expression, and copy number data associated with Patient Derived Xenograft models generated by The Jackson Laboratory has been published in BMC Medical Genomics: Woo XY, Srivastava A, Graber JH, et al: Genomic data analysis workflows for tumors from patient-derived xenografts (PDXs): challenges and guidelines. BMC Medical Genomics volume 12, Article number: 92 (2019). PDX models and their associated data are searchable from the PDX Search Form and from PDX Finder. (July 2019)
  • View the MMHCdb Biocuration 2019 poster: https://doi.org/10.7490/f1000research.1116709.1 (May 2019)
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