Pathology Image Detail

Caption

 This is a densely cellular neoplasm composed of tubules (predominantly), glands, and trabeculae supported by a small amount of fibrovascular stroma.Areas of coagulation necrosis are scattered throughout the neoplasm.

Description

 Mammary gland, adenocarcinoma, tubular, glandular, trabecular, with moderate multifocal coagulation necrosis

Age at Necropsy

 175 days

Contributor

 Mikaelian I (J:94320)

Pathologist

 Mikaelian I (J:94320)

Method

 H&E

Model
MMHC ID
MTB:25614
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
mammary gland, adenocarcinoma, tubular, glandular, trabecular, with moderate multifocal coagulation necrosis
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
B6EiC3Sn a/A-Ts(1716)65Dn/J
Strain Types
radiation induced mutation
translocation
General Note
These mice are segmentally trisomic for chromosome 16 by translocation of part of chromosome 16 to chromosome 17. The genetic background of these mice is approximately 50% C57BL/6JEi and 50% C3SnHeSnJ.
Strain Synonyms
B6EiC3Sn a/A-Ts(1716)65Dn
B6EiC3Sn a/A-Ts(1716)65Dn
B6EiC3Sn-a/A-Ts65Dn
Down syndrome model
segmental trisomy 16
B6EiC3Sn a/A-Ts(1716)65Dn/J
Ts65Dn
Strain Sex
Male
Reproductive Status
reproductive status not specified
Age of Detection
175 days