Pathology Image Detail

Caption

Colon: the superficial portions of the glands in a portion of the colon show neoplastic transformation characterized by the formation of anastomosed and contoured glands lined by a columnar epithelium and supported by a small amount of fibrovascular stroma. The epithelium of these neoplastic glands is more basophilic than the epithelium of the adjacent colonic glands. Their nucleus is large and has a more clumped chromatin than the nucleus of non-neoplastic glands. Mitoses are numerous. A few neoplastic glands are moderately distended by mucin. A few neoplastic cells are apoptotic. There is no evidence of invasion of the stroma.

Description

Adenoma, colon

Age at Necropsy

84 days

Contributor

Kemp CJ (J:97126)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:25615
Tumor Name
Intestine - Large Intestine - Colon • adenoma
Treatment Type
None (spontaneous)
Tumor Synonyms
colon adenoma
Organ Affected
Intestine - Large Intestine - Colon
Frequency
observed
Reference
J:94320

Strain

Strain
C57BL/6-ApcMin/+
Strain Types
chemically induced mutation
General Note
Heterozygous mice. These mice are the product of an intercross between strains on a predominantly C57BL/6 background.
Strain Synonyms
Min/+ p27+/+
B6.Cg-ApcMin/+
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
84 days