Pathology Image Detail

Caption

Colon: the neoplasm is characterized by the formation of slightly contoured and anastomosed glands lined by a one cell-thick columnar epithelium supported by a small amount of fibrovascular stroma. Neoplastic cells have indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, oriented in the long axis of the cell, and with a clumped chromatin. Mitoses are numerous. A moderate number of apoptotic neoplastic cells (arrowhead) are scattered throughout the neoplasm.

Description

Adenoma, colon

Age at Necropsy

84 days

Contributor

Kemp CJ (J:97126)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:25615
Tumor Name
Intestine - Large Intestine - Colon • adenoma
Treatment Type
None (spontaneous)
Tumor Synonyms
colon adenoma
Organ Affected
Intestine - Large Intestine - Colon
Frequency
observed
Reference
J:94320

Strain

Strain
C57BL/6-ApcMin/+
Strain Types
chemically induced mutation
General Note
Heterozygous mice. These mice are the product of an intercross between strains on a predominantly C57BL/6 background.
Strain Synonyms
Min/+ p27+/+
B6.Cg-ApcMin/+
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
84 days