Pathology Image Detail

Caption

Colonic adenoma: this high power photomicrograph illustrates the difference between the normal epithelium (lower left corner of the photomicrograph) and the neoplastic epithelium. Neoplastic cells are columnar. They have a more basophilic cytoplasm compared to non-neoplastic cells and never contain a mucus vacuole. Their nucleus is bigger and with a more clumped chromatin than neoplastic cells. Mitotic rate is elevated. A few degenerated neoplastic cells are in the lumen of some neoplastic glands.

Description

Adenoma (intermediate stage), colon

Age at Necropsy

84 days

Contributor

Kemp CJ (J:97126)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:25615
Tumor Name
Intestine - Large Intestine - Colon • adenoma
Treatment Type
None (spontaneous)
Tumor Synonyms
colon adenoma
Organ Affected
Intestine - Large Intestine - Colon
Frequency
observed
Reference
J:94320

Strain

Strain
C57BL/6-ApcMin/+
Strain Types
chemically induced mutation
General Note
Heterozygous mice. These mice are the product of an intercross between strains on a predominantly C57BL/6 background.
Strain Synonyms
Min/+ p27+/+
B6.Cg-ApcMin/+
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
84 days