Pathology Image Detail

Caption

 Type P mammary adenocarcinoma, immunohistochemistry for keratins 8/18: cytoplasmic labeling for keratins 8/18 is moderate for the large acidophilic cells and weak for most of the small basophilic cells. In addition, there is a continuous row of unlabeled basal cells with a myoepithelial phenotype. Cytoplasmic staining of macrophages in the stroma and in the ducts is the result of endogenous peroxidase activity which could not be totally quenched.

Description

 Mammary adenocarcinoma type P, immunohistochemistry for keratins 8/18

Age at Necropsy

 256 days

Contributor

 Mikaelian I (J:94320)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for keratin 8 and 18
Image Probes

Type: antibody
Name
anti-keratins 8 and 18 (CBL170)
Target
human keratin 8 and 18
Supplier
Chemicon
Notes
Monoclonal antibody raised against cytokeratins from human breast carcinoma cell line MCF-7.

Model
MMHC ID
MTB:25809
Tumor Name
Mammary gland • adenocarcinoma - type P
Treatment Type
None (spontaneous)
Tumor Synonyms
mammary adenocarcinoma, type P
type P mammary adenocarcinoma
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
BALB/cJ
Strain Types
inbred
Strain Synonyms
B alb C
BALB/cJ, H-2d
Balb/CJ
BALB/cJax
BALB
C
Balb/cJ
BALBc
WT
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
256 days