Pathology Image Detail

Caption

Mammary gland: the mammary gland is effaced by a densely cellular, nodular, unencapsulated, well-delineated, densely cellular neoplasm. The neoplasm is composed of trabeculae made up of glands lined by a one cell-thick epithelium. There is central necrosis (*) at the center of the trabeculae (comedo pattern). The stroma is scarce. Neoplastic cells are polygonal to cuboidal, with distinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central to basal, oval and hyperchromatic. Anisocytosis and anisokaryosis are mild.

Description

Adenocarcinoma, glandular, comedo, mammary gland

Age at Necropsy

unknown

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:25960
Tumor Name
Mammary gland • adenocarcinoma - comedo
Treatment Type
None (spontaneous)
Tumor Synonyms
adenocarcinoma, glandular, comedo, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
129-Ifngr1tm1Agt/J
Strain Types
targeted mutation (knockout)
General Note
Homozygous mice.
Strain Synonyms
129-Ifngrtm1Agt
129-Ifngrtm1Agt/J
129-Ifngrtm1Agt/J
IFN-γR0
Strain Sex
Male
Reproductive Status
reproductive status not specified
Age of Detection
unknown