Caption |
Mammary gland: the mammary gland is effaced by a densely cellular, nodular, unencapsulated, well-delineated, densely cellular neoplasm. The neoplasm is composed of trabeculae made up of glands lined by a one cell-thick epithelium. There is central necrosis (*) at the center of the trabeculae (comedo pattern). The stroma is scarce. Neoplastic cells are polygonal to cuboidal, with distinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central to basal, oval, hyperchromatic, with a coarsely clumped chromatin and 1-2 small basophilic nucleoli. Anisocytosis and anisokaryosis are mild. Mitotic index is high. Some eosinophils (arrowheads) are present in the lumen of blood vessels and in the stroma. |