Pathology Image Detail

Caption

Haired skin: neoplastic trabeculae and nests comprise a basal layer of cells, 3-10 layers of cells resembling the cells of the stratum spinosum, and a variably thick layer of cells resembling the cells of the stratum granulosum. Most neoplastic structures are moderately distended by cornified material. Small islets of neoplastic cells have invaded the stroma (at the center of the photomicrograph). Neoplastic cells are large, polygonal, with distinct cell borders, occasionally intercellular bridges, and a moderate to large amount of strongly acidophilic cytoplasm. The nucleus is central, oval, medium-sized, and slightly hypochromatic. Anisocytosis and anisokaryosis are mild. Mitoses are rare.

Description

Squamous cell carcinoma, well-differentiated, haired skin

Age at Necropsy

156 days

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:26089
Tumor Name
Skin • squamous cell carcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
squamous cell carcinoma, well-differentiated, haired skin
Organ Affected
Skin
Frequency
observed
Reference
J:94320

Strain

Strain
B6.129P2-Apoa1tm1Unc/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Homozygous mice. Backcrossed to C57BL/6J.
Strain Synonyms
Apoa1 -/-
B6.129P2-Apoa1tm1Unc
C57BL/6J-Apoa1tm1Unc
Apo A1-
Strain Sex
Male
Reproductive Status
reproductive status not specified
Age of Detection
156 days