Pathology Image Detail

Caption

Undifferentiated sarcoma: the neoplasm is composed of bundles separated by a moderate amount of loose fibrovascular stroma with a prominent granulocytic infiltration. Neoplastic cells are very large, oat-shaped to fusiform, with distinct cell borders and a large amount of amphophilic fibrillar cytoplasm with occasionally a few small acidophilic areas. The nucleus generally is cental, large to very large, and hypochromatic. Anisokaryosis and anisocytosis are severe.

Description

Sarcoma, undifferentiated, subcutis

Age at Necropsy

147 days

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:26699
Tumor Name
Mesodermal cell/mesoblast • sarcoma - undifferentiated
Treatment Type
None (spontaneous)
Tumor Synonyms
sarcoma, undifferentiated, subcutis
Organ Affected
Subcutis
Frequency
observed
Reference
J:94320

Strain

Strain
B6.129S2-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Heterozygous mice. The genetic background of these mice is congenic C57BL/6J.
Strain Synonyms
B6.129S2-Trp53tm1Tyj
C57BL/6J-Trp53tm1Tyj
p53+/-
p53 heterozygous (+/-)
C57BL/6J-Trp53tm1Tyj
p53(+/-)
B6.129S2-Trp53tm1Tyj
p53+/-
p53+/-
Strain Sex
Male
Reproductive Status
reproductive status not specified
Age of Detection
147 days