Pathology Image Detail

Caption

 This high magnification figure allows to better visualize cytological features of neoplastic lymphocytes. Neoplastic lymphocytes form closely packed sheets. They are round, with indistinct cell borders and a scant amount of amphophilic cytoplasm. The nucleus is central, round, medium-sized and hyperchromatic. Anisokaryosis and anisocytosis are mild. Mitotic rate is high and numerous neoplastic cells undergo single cell necrosis.

Description

 Lymphoma, thymic

Age at Necropsy

 107 days

Contributor

 Sundberg J (J:94307)

Pathologist

 Mikaelian I (J:94320)

Method

 H&E

Model
MMHC ID
MTB:26704
Tumor Name
Leukocyte - Lymphocyte • lymphoma
Treatment Type
None (spontaneous)
Tumor Synonyms
thymic lymphoma
Organ Affected
Thymus
Frequency
observed
Reference
J:94320

Strain
Strain
C3Ou.129S2(B6)-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Heterozygous mice. Mice carrying this mutation on a mixed 129S2 x C57BL/6 genetic background were backcrossed at least 5 times to C3H/HeOuJ.
Strain Synonyms
C3Ou.129S2(B6)-Trp53tm1Tyj
C3H/HeOuJ-Trp53tm1Tyj
C3Ou.129S2-Trp53tm1Tyj/J
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
107 days