Pathology Image Detail

Caption

 Mammary adenocarcinoma with epithelial to mesenchymal transition, immunohistochemistry for alpha smooth muscle actin: numerous alpha smooth muscle actin-positive and -negative spindloid cells are present between alpha smooth muscle actin-negative neoplastic glands. Alpha smooth muscle actin-positive cells may represent neoplastic spindloid cells or myofibroblasts.

Description

 Adenocarcinoma with epithelial to mesenchymal transition, immunohistochemistry for alpha smooth muscle actin, mammary gland

Age at Necropsy

 unknown

Contributor

 Fancher K (J:97128)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for smooth muscle actin
Image Probes

Type: antibody
Name
anti-alpha smooth muscle actin (A2547)
Target
alpha-smooth muscle actin, N-terminus
Supplier
Sigma-Aldrich
Notes
Monoclonal anti-Alpha Smooth Muscle Actin antibody produced in mouse (raised against N-terminal synthetic decapeptide of alpha-smooth muscle actin). The antibody (also known as anti-a-Sm-1) is specific for the single isoform of alpha-smooth muscle actin.

Model
MMHC ID
MTB:26706
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
adenocarcinoma with epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
C57BL/6J-Tg(WapTAg)1Knw/J
Strain Types
transgenic
Strain Synonyms
C57BL/6J-Tg(WapTAg)1Knw
WapTag 1
WAPTag 1
C57BL/6J WAPTag 1
WAP-SV40 Tag
WAPTag
C57BL/6J-TgN(WapTAg)1Knw
C57BL6/J-Tag
WAPT1
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown