Pathology Image Detail

Caption

 Mammary adenocarcinoma with epithelial to mesenchymal transition, immunohistochemistry for keratins 8/18: there is strong cytoplasmic labeling of most spindloid cells for keratins 8/18. Cells with a luminal phenotype located in neoplastic glands show moderate apical labeling for keratins 8/18.

Description

 Adenocarcinoma with epithelial to mesenchymal transition, immunohistochemistry for keratins 8/18, mammary gland

Age at Necropsy

 unknown

Contributor

 Fancher K (J:97128)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for keratin 8 and 18
Image Probes

Type: antibody
Name
anti-keratins 8 and 18 (CBL170)
Target
human keratin 8 and 18
Supplier
Chemicon
Notes
Monoclonal antibody raised against cytokeratins from human breast carcinoma cell line MCF-7.

Model
MMHC ID
MTB:26706
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
adenocarcinoma with epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
C57BL/6J-Tg(WapTAg)1Knw/J
Strain Types
transgenic
Strain Synonyms
C57BL/6J-Tg(WapTAg)1Knw
WapTag 1
WAPTag 1
C57BL/6J WAPTag 1
WAP-SV40 Tag
WAPTag
C57BL/6J-TgN(WapTAg)1Knw
C57BL6/J-Tag
WAPT1
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown