Pathology Image Detail

Caption

 Papillary mammary adenocarcinoma, immunohistochemistry for alpha smooth muscle actin: myofibroblasts located in the stroma of the neoplasm show strong cytoplasmic labeling for alpha smooth muscle actin. Neoplastic cells are not labeled.

Description

 Adenocarcinoma, papillary, immunohistochemistry for alpha smooth muscle actin, mammary gland

Age at Necropsy

 unknown

Contributor

 Fancher K (J:97128)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for alpha smooth muscle actin
Image Probes

Type: antibody
Name
anti-alpha smooth muscle actin (A2547)
Target
alpha-smooth muscle actin, N-terminus
Supplier
Sigma-Aldrich
Notes
Monoclonal anti-Alpha Smooth Muscle Actin antibody produced in mouse (raised against N-terminal synthetic decapeptide of alpha-smooth muscle actin). The antibody (also known as anti-a-Sm-1) is specific for the single isoform of alpha-smooth muscle actin.

Model
MMHC ID
MTB:26709
Tumor Name
Mammary gland • adenocarcinoma - papillary
Treatment Type
None (spontaneous)
Tumor Synonyms
adenocarcinoma, papillary, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
C57BL/6J-Tg(WapTAg)3Knw/J
Strain Types
transgenic
Strain Synonyms
C57BL/6J-Tg(WapTAg)3Knw
C57BL/6J-Tg(WAPTAg)3Knw/J
C57BL/6J-TgN(WAPTAg)3Knw
C57BL/6J-TgN(WapTAg)3Knw
C57BL/6J WAPTag 3
WAPTag
WAP-SV40 Tag
WAPTag 3
WAPTag3
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown