Pathology Image Detail

Caption

This photomicrograph illustrates immunohistochemical labeling for keratin 14 of the junction between an area of ductal carcinoma in situ and a non-neoplastic mammary duct. Keratin 14 is expressed only by luminal cells in the area of ductal carcinoma in situ (left portion of the photomicrograph). The duct which appeared normal on the H&E section (right portion of the photomicrograph) lacks myoepithelial differentiation (absence of myoepithelial cells as assessed by the absence of expression of keratin 14 by myoepithelial cells).

Description

Glandular adenocarcinoma, keratin 14 immunolabeling, mammary gland

Age at Necropsy

unknown

Contributor

Fancher K (J:97128)

Pathologist

Mikaelian I (J:94320)

Method

IHC for keratin 14
Image Probes

Type: antibody

Name
anti-keratin 14 (PRB-155P)
Target
mouse keratin 14, C-terminus
Supplier
Biolegend, formerly Covance
Notes
Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 14 protein, KVVSTHEQVLRTKN.

Model

MMHC ID
MTB:26713
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
glandular adenocarcinoma, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
C57BL/6J-Tg(WapTAg)3Knw/J
Strain Types
transgenic
Strain Synonyms
C57BL/6J-Tg(WapTAg)3Knw
C57BL/6J-Tg(WAPTAg)3Knw/J
C57BL/6J-TgN(WAPTAg)3Knw
C57BL/6J-TgN(WapTAg)3Knw
C57BL/6J WAPTag 3
WAPTag
WAP-SV40 Tag
WAPTag 3
WAPTag3
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown