Pathology Image Detail

Caption

Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, and moderately cellular neoplasm. The neoplasm is composed of interconnected branching ducts embedded is a large amount of a fibrovascular stroma characterized with interstitial edema, deposition of numerous and thick wavy collagen fibers, and the presence of numerous spindloid cells consistent with myofibroblasts. Neoplastic glands are lined by a two cells-thick epithelium: cells of the basal layer resemble myoepithelial cells of the mammary gland while cells of the luminal layer resemble luminal cells of the mammary gland. Neoplastic luminal cells often contain lipid vacuoles of various sizes.

Description

Adenocarcinoma, glandular, secretory, with prominent interstitial fibrosis, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29192
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, glandular, secretory, with prominent interstitial fibrosis, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB-Tg(WapTgfa)215Bri
Strain Types
transgenic
Strain Synonyms
FVB-Tg(WapTgfa)#Eps
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown