Pathology Image Detail

Caption	Squamous cell carcinoma of the eyelid. Cells of the upper portions of the epidermis stain strongly brown for filaggrin. Neoplastic cells do not stain.
Description	Eyelid, squamous cell carcinoma
Age at Necropsy	510 days
Contributor	Mikaelian I (J:94310)
Pathologist	Mikaelian I (J:94310)
Method	IHC for filaggrin

Image Probes
Type: antibody	Name anti-filaggrin (PRB-417P) Target filaggrin, residues 24-39 Supplier Covance Notes Monospecific polyclonal rabbit antibody raised against a peptide corresponding to residues 24-39 in the partial sequence of filaggrin, DSQVHSGVQVEGRRGH. This antibody was subsequently purified using peptide affinity chromatography.

General Note: Mice homozygous for a spontaneous (recessive) mutation, Lgi4^clp.