Pathology Image Detail

Caption

Comedo mammary adenocarcinoma: the neoplasm is composed of thick trabeculae and solid areas supported by a small amount of fibrovascular stroma. Neoplastic cells are medium-sized, polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-sized, hypochromatic, with 1-2 large basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Numerous neoplastic cells undergo single cell necrosis.

Description

Adenocarcinoma, circumscribed, solid, comedo, glandular, mammary gland

Age at Necropsy

120 days

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29199
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, circumscribed, solid, comedo, glandular, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
Strain Types
transgenic
General Note
Double transgenic mice. The genetic background of these mice is a mixture of C57BL/6 and SJL.
Strain Synonyms
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
120 days