Pathology Image Detail

Caption

Solid mammary adenocarcinoma: the secondary lumens are filled by a proteinaceous fluid. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, slightly hypochromatic, with a stippled chromatin and 1-2 medium-sized and strongly basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.

Description

Adenocarcinoma, solid, with secondary lumens and epithelial to mesenchymal transition

Age at Necropsy

120 days

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29201
Tumor Name
Mammary gland • adenocarcinoma - solid
Treatment Type
None (spontaneous)
Tumor Synonyms
Mammary gland - Adenocarcinoma, solid, with secondary lumens and epithelial to mesenchymal transition
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
Strain Types
transgenic
General Note
Double transgenic mice. The genetic background of these mice is a mixture of C57BL/6 and SJL.
Strain Synonyms
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
120 days