Pathology Image Detail

Caption

Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas with central necrosis supported by a small amount of fibrovascular stroma. Neoplastic cells are medium-sized to large, polygonal, with ill-defined cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, medium-size, occasionally with a slightly contoured nuclear membrane, slightly hypochromatic and with 1-3 medium size basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitotic rate is elevated. A moderate number of neoplastic cells undergoes apoptosis.

Description

Adenocarcinoma, solid, comedo, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29202
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, solid, comedo, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB.Cg-Tg(WapMyc)212Bri Tg(WapTgfa)215Bri
Strain Types
congenic
transgenic
General Note
The genetic background of these mice was FVB/N. Both transgenes were originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapTgfa)(WapMyc)#Led
FVB/N-Tg(WapMyc)212Bri Tg(WapTgfa)215Bri
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown