Pathology Image Detail

Caption

Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas supported by a small amount of fibrovascular stroma. Neoplastic cells are medium-sized to large, polygonal, with ill-defined cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, medium-size, occasionally with a slightly contoured nuclear membrane, slightly hypochromatic and with 1-3 medium size basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitotic rate is elevated. A moderate number of neoplastic cells undergoes apoptosis. Necrosis and cavitation are present at the center of the largest trabeculae.

Description

Adenocarcinoma, solid, comedo, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29202
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, solid, comedo, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB.Cg-Tg(WapMyc)212Bri Tg(WapTgfa)215Bri
Strain Types
congenic
transgenic
General Note
The genetic background of these mice was FVB/N. Both transgenes were originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapTgfa)(WapMyc)#Led
FVB/N-Tg(WapMyc)212Bri Tg(WapTgfa)215Bri
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown