Pathology Image Detail

Caption

Mammary gland: the neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, generally basal, medium-sized, normochromatic, with a finely stippled chromatin and 1-4 medium-sized basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present. There is a mild lymphocytic and granulocytic infiltrate at the periphery of the neoplasm.

Description

Adenocarcinoma, glandular, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29203
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, glandular, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
B6;C-Tg(MMTV-RET)127Ina
Strain Types
transgenic
General Note
The genetic background of these mice was a mixture of C57BL/6 and BALB/c.
Strain Synonyms
(C57BL6xBalb/c)-Tg(MMTVRet)1Ina
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown