Pathology Image Detail

Caption

Mammary gland: hypercellularity of mammary lobules is the result of proliferation of luminal cells of mammary alveoli and intralobular ducts. These cells pile-up and occlude the lumen of some alveoli. The cells populating this lobule are very heterogeneous. About 30% of these cells have primitive features: they are oval, with a pale acidophilic cytoplasm and a medium-sized slightly hypochromatic nucleus. The other cells are more differentiated and have a cuboidal to low columnar shape, a more strongly acidophilic cytoplasm and a normochromatic nucleus. There is no evidence of atypia but a few mitoses (arrowheads) are detected. There is no evidence of local invasion. There is mild interstitial fibrosis and lymphocytic and plasmacytic inflammation.

Description

Carcinoma in situ, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29205
Tumor Name
Mammary gland • carcinoma in situ
Treatment Type
None (spontaneous)
Tumor Synonyms
Carcinoma in situ, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
B6;C-Tg(MMTV-RET)127Ina
Strain Types
transgenic
General Note
The genetic background of these mice was a mixture of C57BL/6 and BALB/c.
Strain Synonyms
(C57BL6xBalb/c)-Tg(MMTVRet)1Ina
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown