Pathology Image Detail

Caption

Mammary gland: there is moderate diffuse expansion of a mammary lobule. Within this lobule, a few acini are markedly expanded by closely packed epithelial cells that form solid areas and small glands with an inconspicuous lumen. The cells are polygonal, with distinct cell borders and a moderate amount of pale acidophilic cytoplasm. The nucleus is central, oval, medium-sized and hypochromatic. Anisokaryosis and anisocytosis are mild. There is no evidence of local invasion. Mitotic figures are numerous. A small focus of cornification (arrowhead) is present.There is moderate interstitial lymphocytic and plasmacytic inflammation and fibrosis.

Description

Carcinoma in situ, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29207
Tumor Name
Mammary gland • carcinoma in situ
Treatment Type
None (spontaneous)
Tumor Synonyms
Carcinoma in situ, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
B6;C-Tg(MMTV-RET)127Ina
Strain Types
transgenic
General Note
The genetic background of these mice was a mixture of C57BL/6 and BALB/c.
Strain Synonyms
(C57BL6xBalb/c)-Tg(MMTVRet)1Ina
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown