Pathology Image Detail

Caption

Mammary gland: there is moderate diffuse expansion of a mammary lobule. Within this lobule, a few acini are markedly expanded by closely packed epithelial cells that form solid areas and small glands with an inconspicuous lumen. The cells are polygonal, with distinct cell borders and a moderate amount of pale acidophilic cytoplasm. The nucleus is central, oval, medium-sized and hypochromatic. Anisokaryosis and anisocytosis are mild. There is no evidence of local invasion. Mitotic figures are numerous. There is moderate interstitial lymphocytic and plasmacytic inflammation and fibrosis. Myoepithelial differentiation is prominent and appears as a continuous layer of cells with a nucleus oriented parallel to the basement membrane and a scant amount of cytoplasm.

Description

Carcinoma in situ, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29207
Tumor Name
Mammary gland • carcinoma in situ
Treatment Type
None (spontaneous)
Tumor Synonyms
Carcinoma in situ, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
B6;C-Tg(MMTV-RET)127Ina
Strain Types
transgenic
General Note
The genetic background of these mice was a mixture of C57BL/6 and BALB/c.
Strain Synonyms
(C57BL6xBalb/c)-Tg(MMTVRet)1Ina
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown