Pathology Image Detail

Caption

In situ mammary carcinoma: this represents an early stage of in situ mammary carcinoma: the architecture of the mamamry gland is preserved but mammary lobules are packed with epithelial cells and often lack a lumen. Numerous cells in the mammary gland are round, have a very pale cytoplasm with a ground glass appearance, and have a medium-sized hypochromatic nucleus. These features are consistent with the features of a primitive epithelial cell. There is mild to moderate interstitial lymphocytic and plasmacytic inflammation. Myoepithelial differentiation is still detected and myoepithelial cells appear as cells with an ellongated nucleus parallel to the basement membrane and a scant amount of cytoplasm.

Description

Carcinoma in situ, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29207
Tumor Name
Mammary gland • carcinoma in situ
Treatment Type
None (spontaneous)
Tumor Synonyms
Carcinoma in situ, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
B6;C-Tg(MMTV-RET)127Ina
Strain Types
transgenic
General Note
The genetic background of these mice was a mixture of C57BL/6 and BALB/c.
Strain Synonyms
(C57BL6xBalb/c)-Tg(MMTVRet)1Ina
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown