Caption |
In situ mammary carcinoma: this photomicrograph represents the transition from the early stages of in situ mammary carcinoma to a more advanced stage of the disease (at the center of the photomicrograph). Myoepithelial differentiation is prominent in the areas of early in situ mammary carcinoma. It is still present but difficult to identify in the more advance areas. Cells in the more advanced areas are larger, with pale acidophilic cytoplasm and a medium-sized hypochromatic nucleus. Cells in the least advanced areas are smaller and have a smaller and normo- to hyperchromatic nucleus. There is no evidence of invasion. There is mild interstitial lymphocytic and plasmacytic inflammation and fibrosis. |
