Pathology Image Detail

Caption

Mammary gland: the mammary gland is effaced by a large, nodular, multilobular, unencapsulated, densely cellular, neoplastic mass. This mass is composed of large coalescing lobules separated by a scant amount of loose fibrovascular stroma with large ectatic vascular spaces (*). Necrosis and cavitation are common in most neoplastic lobules. The portion of the neoplasm located at the center of the photomicrograph is composed of large polygonal cells with distinct cell borders, a large amount of acidophilic cytoplasm, and medium-size hypochromatic nuclei. The portions of the neoplasm located at the periphery of this photomicrograph are composed of crowded small cells with indistinct cell borders, a small amount of acidophilic cytoplasm, and a slightly smaller and more hypochromatic nucleus. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.

Description

Adenocarcinoma, solid, comedo, with microinvasion, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29234
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, solid, comedo, with microinvasion, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
Strain Types
transgenic
Strain Synonyms
FVB/N-TgN(MMTVneu)202Mul TgN(Trp53R172H)8512Jmr
bitransgenic
line 8512 WAP-p53-172H line N# 202 MMTV-neu
WAP-p53-172H MMTV-neu
p53-172H/neu bitransgenic
FVB/N-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown