Pathology Image Detail

Caption

Solid mammary carcinoma: this photomicrograph illustrates an asymmetrical mitotic figure (arrowhead). Asymmetrical figures generally are not observed in mice transgenic for neu. However, mice transgenic for neu and with Trp53 mutations often develop tumors with prominent asymmetrical mitotic figures. A few neoplastic cells at the right of the photomicrograph contain lipid vacuoles. A few neoplastic cells at the left of the photomicrograph are undergoing single cell necrosis.

Description

Adenocarcinoma, solid, comedo, with microinvasion, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29234
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, solid, comedo, with microinvasion, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
Strain Types
transgenic
Strain Synonyms
FVB/N-TgN(MMTVneu)202Mul TgN(Trp53R172H)8512Jmr
bitransgenic
line 8512 WAP-p53-172H line N# 202 MMTV-neu
WAP-p53-172H MMTV-neu
p53-172H/neu bitransgenic
FVB/N-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown