Pathology Image Detail

Caption

Mammary gland: the microadenoma is composed of closely-packed glands lined by a one cell-thick low columnar epithelium and supported by a small amount of fibrovascular stroma. Neoplastic cells are low columnar, with indistinct cell borders and a moderate amount of acidophilic cytoplasm that occasionally contains a few lipid vacuoles. The nucleus is basal, round, medium-sized and normochromatic. Anisokaryosis is moderate. Anisocytosis is mild. A few mitoses, including asymmetrical mitoses (arrowhead) are noted.

Description

Adenoma, glandular, with prominent atypia, and diffuse hyperplasia with atypia, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29238
Tumor Name
Mammary gland • adenoma
Treatment Type
Chemical/Drug
Agents
[Agent] - Agent._Agent_key = [7] - Agent._AgentType_key = [3] - Agent.name = [7,12-dimethylbenz[a]anthracene (DMBA)] - Agent.description = [null] - Agent.create_user = [MTB] - Agent.create_date = [2005-01-05 13:31:30.0] - Agent.update_user = [dmk] - Agent.update_date = [2007-06-26 11:16:55.0]
[Agent] - Agent._Agent_key = [2] - Agent._AgentType_key = [5] - Agent.name = [pituitary isograft] - Agent.description = [null] - Agent.create_user = [MTB] - Agent.create_date = [2005-01-05 13:31:30.0] - Agent.update_user = [MTB] - Agent.update_date = [2005-01-05 13:31:30.0]
Tumor Synonyms
Adenoma, glandular, with prominent atypia, and diffuse hyperplasia with atypia, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB-Tg(Trp53R172H)8512Jmr
Strain Types
transgenic
Strain Synonyms
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown