Pathology Image Detail

Caption

Mammary gland: this is a portion of a moderately to densely cellular neoplasm. This neoplasm is composed of glands and tubules lined by a one cell-thick cuboidal epithelium supported by an abundant amount of fibrovascular stroma. The stroma is infiltrated by a moderate number of granulocytes, lymphocytes and plasma cells. Neoplastic cells are cuboidal, medium-size, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm that often contains lipid vacuoles. The nucleus is basal, oval, medium-size to large, and generally hyperchromatic. Anisokaryosis and anisocytosis are moderate. A few mitoses are detected.

Description

Adenocarcinoma, glandular, with prominent fibrosis and granulocytic inflammation, mammary gland

Age at Necropsy

unknown

Notes

This neoplasm shares many similarities with fibroadenomas. However, the extent of atypia and the asymmetrical mitoses warrant a diagnosis of adenocarcinoma.

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29240
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, glandular, with prominent fibrosis and granulocytic inflammation, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB-Tg(Trp53R172H)8512Jmr
Strain Types
transgenic
Strain Synonyms
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown