Pathology Image Detail

Caption

Mammary gland: the mammary gland is replaced by a densely cellular neoplasm composed of closely-packed glands and branching ducts lined by a 1-2 cells-thick cuboidal epithelium and separated by a small amount of fibrovascular stroma. Some ducts are moderately ectatic and filled by a strongly acidophilic amorphous material and desquamated neoplastic cells. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, round to oval, occasionally oriented in the long axis of the cell, medium-size, hyperchromatic, with a coarsely clumped chromatin and 1-4 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.

Description

Adenocarcinoma, glandular, with prominent coagulation necrosis, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29267
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, glandular, with prominent coagulation necrosis, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
NMRI-Tg(Wap-Tag)8Gmn
Strain Types
transgenic
Strain Synonyms
NMRI-Tg(Wap-SV40)1Gmn
WAP-SVT/t, line 8
WAP-SVT/t
WAP-SVT/t (strain NMRI)
WAP-SV-T
WAP-SV-T line 8
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown